1. use of home oxygen at baseline 2. current use of mechanical ventilation 3. inability to provide consent 4. do not intubate status 5. prisoner or incarcerated 6. pregnancy or breast feeding 7. participation in other interventional therapy trials for covid-19. 8. international normalized ratio (inr) \> 3 or activated partial thromboplastin time (aptt) \> 60

1. use of home oxygen at baseline 2. current use of mechanical ventilation 3. inability to provide consent 4. do not intubate status 5. prisoner or incarcerated 6. pregnancy or breast feeding 7. participation in other interventional therapy trials for covid-19. 8. international normalized ratio (inr) \> 3 or activated partial thromboplastin time (aptt) \> 60

use of home oxygen at baseline current use of mechanical ventilation inability to provide consent do not intubate status prisoner or incarcerated pregnancy or breast feeding participation in other interventional therapy trials for covid-19. international normalized ratio (inr) > 3 or activated partial thromboplastin time (aptt) > 60

use of home oxygen at baseline current use of mechanical ventilation inability to provide consent do not intubate status prisoner or incarcerated pregnancy or breast feeding participation in other interventional therapy trials for covid-19. international normalized ratio (inr) > 3 or activated partial thromboplastin time (aptt) > 60

1. use of home oxygen at baseline 2. current use of mechanical ventilation 3. inability to provide consent 4. do not intubate status 5. prisoner or incarcerated 6. pregnancy or breast feeding 7. participation in other interventional therapy trials for covid-19. 8. international normalized ratio (inr) > 3 or activated partial thromboplastin time (aptt) > 60

1. use of home oxygen at baseline 2. current use of mechanical ventilation 3. inability to provide consent 4. do not intubate status 5. prisoner or incarcerated 6. pregnancy or breast feeding 7. participation in other interventional therapy trials for covid-19. 8. international normalized ratio (inr) > 3 or activated partial thromboplastin time (aptt) > 60