1. severe type of disease, with at least one of the following criteria: * frequency of breath \> 35 per minute, which does not decrease after the body temperature drops to normal or subfebrile values; * blood oxygen saturation (spo2) \< 90% at rest; * partial pressure of oxygen in arterial blood (pao2) \< 60 mm hg; * oxygenation index (rao2/fio2) ≤ 200 mm hg; * partial pressure of co2 in arterial blood (paco2) \< 60 mm hg; * septic shock. 2. patients treated with lopinavir/ritonavir, ribavirin, arbidol, chloroquine, hydroxychloroquine, mefloquine, favipiravir within 7 days prior to screening. 3. severe cardiovascular diseases currently or 6 months prior to randomization, including: new york heart association (nyha) class iii or iv chronic heart failure, clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant valvular heart disease, uncontrolled arterial hypertension with systolic blood pressure \> 180 mm hg and diastolic blood pressure \> 110 mm hg, pulmonary embolism or deep vein thrombosis. 4. severe chronic renal impairment (gfr \< 30 ml / min) or continuous renal replacement therapy, hemodialysis or peritoneal dialysis. 5. a history of cirrhosis or an increase in alanine aminotransferase (alt) and / or aspartate aminotransferase (ast) \> 5 times × upper limit of normal (uln). 6. severe diseases of the central nervous system, including seizures in history or conditions that may lead to their development; stroke or transient ischemic attack within 12 months prior to screening; head injuries or loss of consciousness within 12 months prior to screening; a brain tumor. 7. significant uncontrolled concomitant disease, e.g. neurological, renal, hepatic, endocrinological or gastrointestinal disorder which according to the investigator, could prevent the patient from participating in the study 8. malignancies that require chemotherapy within 6 months prior to screening. 9. known hiv infection 10. hypersensitivity to any component of the study drug. 11. participation in other clinical studies or taking other study drugs within 28 days prior to screening. 12. pregnant or lactating women or women planning to get pregnant during the clinical study; women of child-bearing potential (including non-sterilized by surgical means and during the post-menopause period less than 2 years) who do not use adequate contraception methods. 13. inability to read or write, unwillingness to understand and follow procedures of study protocol, as well as any other concomitant medical or serious mental conditions that make the patient unfit to participate in the study, limit the legality of obtaining informed consent or can affect patient's ability to participate in the study.

1. severe type of disease, with at least one of the following criteria: * frequency of breath \> 35 per minute, which does not decrease after the body temperature drops to normal or subfebrile values; * blood oxygen saturation (spo2) \< 90% at rest; * partial pressure of oxygen in arterial blood (pao2) \< 60 mm hg; * oxygenation index (rao2/fio2) ≤ 200 mm hg; * partial pressure of co2 in arterial blood (paco2) \< 60 mm hg; * septic shock. 2. patients treated with lopinavir/ritonavir, ribavirin, arbidol, chloroquine, hydroxychloroquine, mefloquine, favipiravir within 7 days prior to screening. 3. severe cardiovascular diseases currently or 6 months prior to randomization, including: new york heart association (nyha) class iii or iv chronic heart failure, clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant valvular heart disease, uncontrolled arterial hypertension with systolic blood pressure \> 180 mm hg and diastolic blood pressure \> 110 mm hg, pulmonary embolism or deep vein thrombosis. 4. severe chronic renal impairment (gfr \< 30 ml / min) or continuous renal replacement therapy, hemodialysis or peritoneal dialysis. 5. a history of cirrhosis or an increase in alanine aminotransferase (alt) and / or aspartate aminotransferase (ast) \> 5 times × upper limit of normal (uln). 6. severe diseases of the central nervous system, including seizures in history or conditions that may lead to their development; stroke or transient ischemic attack within 12 months prior to screening; head injuries or loss of consciousness within 12 months prior to screening; a brain tumor. 7. significant uncontrolled concomitant disease, e.g. neurological, renal, hepatic, endocrinological or gastrointestinal disorder which according to the investigator, could prevent the patient from participating in the study 8. malignancies that require chemotherapy within 6 months prior to screening. 9. known hiv infection 10. hypersensitivity to any component of the study drug. 11. participation in other clinical studies or taking other study drugs within 28 days prior to screening. 12. pregnant or lactating women or women planning to get pregnant during the clinical study; women of child-bearing potential (including non-sterilized by surgical means and during the post-menopause period less than 2 years) who do not use adequate contraception methods. 13. inability to read or write, unwillingness to understand and follow procedures of study protocol, as well as any other concomitant medical or serious mental conditions that make the patient unfit to participate in the study, limit the legality of obtaining informed consent or can affect patient's ability to participate in the study.

severe type of disease, with at least one of the following criteria: frequency of breath > 35 per minute, which does not decrease after the body temperature drops to normal or subfebrile values; blood oxygen saturation (spo2) < 90% at rest; partial pressure of oxygen in arterial blood (pao2) < 60 mm hg; oxygenation index (rao2/fio2) ≤ 200 mm hg; partial pressure of co2 in arterial blood (paco2) < 60 mm hg; septic shock. patients treated with lopinavir/ritonavir, ribavirin, arbidol, chloroquine, hydroxychloroquine, mefloquine, favipiravir within 7 days prior to screening. severe cardiovascular diseases currently or 6 months prior to randomization, including: new york heart association (nyha) class iii or iv chronic heart failure, clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant valvular heart disease, uncontrolled arterial hypertension with systolic blood pressure > 180 mm hg and diastolic blood pressure > 110 mm hg, pulmonary embolism or deep vein thrombosis. severe chronic renal impairment (gfr < 30 ml / min) or continuous renal replacement therapy, hemodialysis or peritoneal dialysis. a history of cirrhosis or an increase in alanine aminotransferase (alt) and / or aspartate aminotransferase (ast) > 5 times × upper limit of normal (uln). severe diseases of the central nervous system, including seizures in history or conditions that may lead to their development; stroke or transient ischemic attack within 12 months prior to screening; head injuries or loss of consciousness within 12 months prior to screening; a brain tumor. significant uncontrolled concomitant disease, e.g. neurological, renal, hepatic, endocrinological or gastrointestinal disorder which according to the investigator, could prevent the patient from participating in the study malignancies that require chemotherapy within 6 months prior to screening. known hiv infection hypersensitivity to any component of the study drug. participation in other clinical studies or taking other study drugs within 28 days prior to screening. pregnant or lactating women or women planning to get pregnant during the clinical study; women of child-bearing potential (including non-sterilized by surgical means and during the post-menopause period less than 2 years) who do not use adequate contraception methods. inability to read or write, unwillingness to understand and follow procedures of study protocol, as well as any other concomitant medical or serious mental conditions that make the patient unfit to participate in the study, limit the legality of obtaining informed consent or can affect patient's ability to participate in the study.

severe type of disease, with at least one of the following criteria: frequency of breath > 35 per minute, which does not decrease after the body temperature drops to normal or subfebrile values; blood oxygen saturation (spo2) < 90% at rest; partial pressure of oxygen in arterial blood (pao2) < 60 mm hg; oxygenation index (rao2/fio2) ≤ 200 mm hg; partial pressure of co2 in arterial blood (paco2) < 60 mm hg; septic shock. patients treated with lopinavir/ritonavir, ribavirin, arbidol, chloroquine, hydroxychloroquine, mefloquine, favipiravir within 7 days prior to screening. severe cardiovascular diseases currently or 6 months prior to randomization, including: new york heart association (nyha) class iii or iv chronic heart failure, clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant valvular heart disease, uncontrolled arterial hypertension with systolic blood pressure > 180 mm hg and diastolic blood pressure > 110 mm hg, pulmonary embolism or deep vein thrombosis. severe chronic renal impairment (gfr < 30 ml / min) or continuous renal replacement therapy, hemodialysis or peritoneal dialysis. a history of cirrhosis or an increase in alanine aminotransferase (alt) and / or aspartate aminotransferase (ast) > 5 times × upper limit of normal (uln). severe diseases of the central nervous system, including seizures in history or conditions that may lead to their development; stroke or transient ischemic attack within 12 months prior to screening; head injuries or loss of consciousness within 12 months prior to screening; a brain tumor. significant uncontrolled concomitant disease, e.g. neurological, renal, hepatic, endocrinological or gastrointestinal disorder which according to the investigator, could prevent the patient from participating in the study malignancies that require chemotherapy within 6 months prior to screening. known hiv infection hypersensitivity to any component of the study drug. participation in other clinical studies or taking other study drugs within 28 days prior to screening. pregnant or lactating women or women planning to get pregnant during the clinical study; women of child-bearing potential (including non-sterilized by surgical means and during the post-menopause period less than 2 years) who do not use adequate contraception methods. inability to read or write, unwillingness to understand and follow procedures of study protocol, as well as any other concomitant medical or serious mental conditions that make the patient unfit to participate in the study, limit the legality of obtaining informed consent or can affect patient's ability to participate in the study.

1. severe type of disease, with at least one of the following criteria: - frequency of breath > 35 per minute, which does not decrease after the body temperature drops to normal or subfebrile values; - blood oxygen saturation (spo2) < 90% at rest; - partial pressure of oxygen in arterial blood (pao2) < 60 mm hg; - oxygenation index (rao2/fio2) ≤ 200 mm hg; - partial pressure of co2 in arterial blood (paco2) < 60 mm hg; - septic shock. 2. patients treated with lopinavir/ritonavir, ribavirin, arbidol, chloroquine, hydroxychloroquine, mefloquine, favipiravir within 7 days prior to screening. 3. severe cardiovascular diseases currently or 6 months prior to randomization, including: new york heart association (nyha) class iii or iv chronic heart failure, clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant valvular heart disease, uncontrolled arterial hypertension with systolic blood pressure > 180 mm hg and diastolic blood pressure > 110 mm hg, pulmonary embolism or deep vein thrombosis. 4. severe chronic renal impairment (gfr < 30 ml / min) or continuous renal replacement therapy, hemodialysis or peritoneal dialysis. 5. a history of cirrhosis or an increase in alanine aminotransferase (alt) and / or aspartate aminotransferase (ast) > 5 times × upper limit of normal (uln). 6. severe diseases of the central nervous system, including seizures in history or conditions that may lead to their development; stroke or transient ischemic attack within 12 months prior to screening; head injuries or loss of consciousness within 12 months prior to screening; a brain tumor. 7. significant uncontrolled concomitant disease, e.g. neurological, renal, hepatic, endocrinological or gastrointestinal disorder which according to the investigator, could prevent the patient from participating in the study 8. malignancies that require chemotherapy within 6 months prior to screening. 9. known hiv infection 10. hypersensitivity to any component of the study drug. 11. participation in other clinical studies or taking other study drugs within 28 days prior to screening. 12. pregnant or lactating women or women planning to get pregnant during the clinical study; women of child-bearing potential (including non-sterilized by surgical means and during the post-menopause period less than 2 years) who do not use adequate contraception methods. 13. inability to read or write, unwillingness to understand and follow procedures of study protocol, as well as any other concomitant medical or serious mental conditions that make the patient unfit to participate in the study, limit the legality of obtaining informed consent or can affect patient's ability to participate in the study.

1. severe type of disease, with at least one of the following criteria: - frequency of breath > 35 per minute, which does not decrease after the body temperature drops to normal or subfebrile values; - blood oxygen saturation (spo2) < 90% at rest; - partial pressure of oxygen in arterial blood (pao2) < 60 mm hg; - oxygenation index (rao2/fio2) ≤ 200 mm hg; - partial pressure of co2 in arterial blood (paco2) < 60 mm hg; - septic shock. 2. patients treated with lopinavir/ritonavir, ribavirin, arbidol, chloroquine, hydroxychloroquine, mefloquine, favipiravir within 7 days prior to screening. 3. severe cardiovascular diseases currently or 6 months prior to randomization, including: new york heart association (nyha) class iii or iv chronic heart failure, clinically significant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), unstable angina, myocardial infarction, heart and coronary vessel surgery, significant valvular heart disease, uncontrolled arterial hypertension with systolic blood pressure > 180 mm hg and diastolic blood pressure > 110 mm hg, pulmonary embolism or deep vein thrombosis. 4. severe chronic renal impairment (gfr < 30 ml / min) or continuous renal replacement therapy, hemodialysis or peritoneal dialysis. 5. a history of cirrhosis or an increase in alanine aminotransferase (alt) and / or aspartate aminotransferase (ast) > 5 times × upper limit of normal (uln). 6. severe diseases of the central nervous system, including seizures in history or conditions that may lead to their development; stroke or transient ischemic attack within 12 months prior to screening; head injuries or loss of consciousness within 12 months prior to screening; a brain tumor. 7. significant uncontrolled concomitant disease, e.g. neurological, renal, hepatic, endocrinological or gastrointestinal disorder which according to the investigator, could prevent the patient from participating in the study 8. malignancies that require chemotherapy within 6 months prior to screening. 9. known hiv infection 10. hypersensitivity to any component of the study drug. 11. participation in other clinical studies or taking other study drugs within 28 days prior to screening. 12. pregnant or lactating women or women planning to get pregnant during the clinical study; women of child-bearing potential (including non-sterilized by surgical means and during the post-menopause period less than 2 years) who do not use adequate contraception methods. 13. inability to read or write, unwillingness to understand and follow procedures of study protocol, as well as any other concomitant medical or serious mental conditions that make the patient unfit to participate in the study, limit the legality of obtaining informed consent or can affect patient's ability to participate in the study.