1. Patients with severe cardiovascular, cerebrovascular, liver, kidney, malignant tumors, hematological diseases, and mental diseases, 2. Severe disturbance of consciousness, dementia or suffering from certain diseases affect the evaluation of curative effect, such as aphasia, visual and hearing impairment, 3. Those who are unable or unwilling to cooperate with rehabilitation assessment, 4. Cognitive disorders, mental disorders, long-term alcohol abuse or a history of illegal drug use, 5. Women who are pregnant or breastfeeding, or have pregnancy plans in next six months, 6. Those who are participating in other clinical trials or have participated in other clinical trials in the past 3 months. 7. Patients judged by the investigator to be unsuitable to participate in this trial.

1. Patients with severe cardiovascular, cerebrovascular, liver, kidney, malignant tumors, hematological diseases, and mental diseases, 2. Severe disturbance of consciousness, dementia or suffering from certain diseases affect the evaluation of curative effect, such as aphasia, visual and hearing impairment, 3. Those who are unable or unwilling to cooperate with rehabilitation assessment, 4. Cognitive disorders, mental disorders, long-term alcohol abuse or a history of illegal drug use, 5. Women who are pregnant or breastfeeding, or have pregnancy plans in next six months, 6. Those who are participating in other clinical trials or have participated in other clinical trials in the past 3 months. 7. Patients judged by the investigator to be unsuitable to participate in this trial.