inclusion criteria: patients with sars-cov-2 infection and 1. age ≥ 18 years and ≤ 75 years 2. sars-cov-2 infection confirmed by pcr (bal, sputum, nasal and/or pharyngeal swap) 3. severe disease defined by at least one of the following: 1. respiratory rate ≥ 30 breaths / minute under ambient air 2. requirement of any type of ventilation support 3. needs icu treatment 4. written informed consent by patient or legally authorized representative

inclusion criteria: patients with sars-cov-2 infection and 1. age ≥ 18 years and ≤ 75 years 2. sars-cov-2 infection confirmed by pcr (bal, sputum, nasal and/or pharyngeal swap) 3. severe disease defined by at least one of the following: 1. respiratory rate ≥ 30 breaths / minute under ambient air 2. requirement of any type of ventilation support 3. needs icu treatment 4. written informed consent by patient or legally authorized representative

inclusion criteria: patients with sars-cov-2 infection and age ≥ 18 years and ≤ 75 years sars-cov-2 infection confirmed by pcr (bal, sputum, nasal and/or pharyngeal swap) severe disease defined by at least one of the following: respiratory rate ≥ 30 breaths / minute under ambient air requirement of any type of ventilation support needs icu treatment written informed consent by patient or legally authorized representative

inclusion criteria: patients with sars-cov-2 infection and age ≥ 18 years and ≤ 75 years sars-cov-2 infection confirmed by pcr (bal, sputum, nasal and/or pharyngeal swap) severe disease defined by at least one of the following: respiratory rate ≥ 30 breaths / minute under ambient air requirement of any type of ventilation support needs icu treatment written informed consent by patient or legally authorized representative

inclusion criteria: patients with sars-cov-2 infection and 1. age ≥ 18 years and ≤ 75 years 2. sars-cov-2 infection confirmed by pcr (bal, sputum, nasal and/or pharyngeal swap) 3. severe disease defined by at least one of the following: 1. respiratory rate ≥ 30 breaths / minute under ambient air 2. requirement of any type of ventilation support 3. needs icu treatment 4. written informed consent by patient or legally authorized representative

inclusion criteria: patients with sars-cov-2 infection and 1. age ≥ 18 years and ≤ 75 years 2. sars-cov-2 infection confirmed by pcr (bal, sputum, nasal and/or pharyngeal swap) 3. severe disease defined by at least one of the following: 1. respiratory rate ≥ 30 breaths / minute under ambient air 2. requirement of any type of ventilation support 3. needs icu treatment 4. written informed consent by patient or legally authorized representative