1. Have history of severe drug or vaccine allergy (anaphylaxis) 2. Have detected COVID-19 infection 3. Have history of COVID-19 high risk contact 4. Have received blood transfusion, plasma, blood product, blood components, immunoglobulins, antiviral or antibodies within the last 90 days 5. Have history of cigarettes smoking, alcohol drinking and history of drug abuse 6. Be pregnant 7. Have unstable disease or could not control the symptom 8. Have history of immunodeficiency or use immunosuppressant or steroid drugs 9. Have any unusual symptoms or medical history that considered unable to participate in the study

1. Have history of severe drug or vaccine allergy (anaphylaxis) 2. Have detected COVID-19 infection 3. Have history of COVID-19 high risk contact 4. Have received blood transfusion, plasma, blood product, blood components, immunoglobulins, antiviral or antibodies within the last 90 days 5. Have history of cigarettes smoking, alcohol drinking and history of drug abuse 6. Be pregnant 7. Have unstable disease or could not control the symptom 8. Have history of immunodeficiency or use immunosuppressant or steroid drugs 9. Have any unusual symptoms or medical history that considered unable to participate in the study