- Have history of severe drug or vaccine allergy (anaphylaxis) - Have detected COVID-19 infection within the last 90 days - Have received blood transfusion, plasma, blood product, blood components, immunoglobulins, antiviral or antibodies within the last 90 days - Have history of cigarettes smoking, alcohol drinking and history of drug abuse - Be pregnant - Have unstable disease or could not control the symptom - Have history of immunodeficiency or use immunosuppressant or steroid drugs - Have any unusual symptoms or medical history that considered unable to participate in the study

- Have history of severe drug or vaccine allergy (anaphylaxis) - Have detected COVID-19 infection within the last 90 days - Have received blood transfusion, plasma, blood product, blood components, immunoglobulins, antiviral or antibodies within the last 90 days - Have history of cigarettes smoking, alcohol drinking and history of drug abuse - Be pregnant - Have unstable disease or could not control the symptom - Have history of immunodeficiency or use immunosuppressant or steroid drugs - Have any unusual symptoms or medical history that considered unable to participate in the study