1) Pregnant or lactating patients.2) Patients with glucose-6-phosphate-dehydrogenase deficiency proven analytically or by their medical history.3) Chronic non-communicable diseases decompensated at the time of initiation of the trial4) Cancer patients for being immunocompromised.5) Patients with uncontrolled hyperthyroidism.6) Patients with psychiatric illnesses, mental retardation or cognitive impairment that imply the psychological incompetence of the subject.7) Scheduled surgery or other procedures that require general anesthesia during the study.8) Patients who use immunosuppressants continuously, or who undergo an organ transplant within 6 months.9) Patients with bleeding disorders, thrombocytopenia, active bleeding or who are under anticoagulant treatment.10) Patients who participated in other clinical trials within the previous three months (eg. Vaccination with COVID 19 candidates)11) Patients who were previously ill with COVID 1912) People with allergies or hypersensitivity to medical ozone.13) Patients with motor disabilities that make it difficult or impossible for them to move autonomously14) Patients with more than two diarrhea a day.

1) Pregnant or lactating patients.2) Patients with glucose-6-phosphate-dehydrogenase deficiency proven analytically or by their medical history.3) Chronic non-communicable diseases decompensated at the time of initiation of the trial4) Cancer patients for being immunocompromised.5) Patients with uncontrolled hyperthyroidism.6) Patients with psychiatric illnesses, mental retardation or cognitive impairment that imply the psychological incompetence of the subject.7) Scheduled surgery or other procedures that require general anesthesia during the study.8) Patients who use immunosuppressants continuously, or who undergo an organ transplant within 6 months.9) Patients with bleeding disorders, thrombocytopenia, active bleeding or who are under anticoagulant treatment.10) Patients who participated in other clinical trials within the previous three months (eg. Vaccination with COVID 19 candidates)11) Patients who were previously ill with COVID 1912) People with allergies or hypersensitivity to medical ozone.13) Patients with motor disabilities that make it difficult or impossible for them to move autonomously14) Patients with more than two diarrhea a day.