1. The new crown vaccine is planned, 2. Elderly subjects aged 60-80 and young and middle-aged subjects aged 18 to 59 years, 3. The subjects can and are willing to comply with the requirements of the clinical trial protocol, complete the 12-month study follow-up and sign the informed consent, 4. HBsAg, anti HCV, HIV and TPHA screening were negative, 5. The new crown RNA test was negative, 6. Axillary body temperature <=37.0 degree C.

1. The new crown vaccine is planned, 2. Elderly subjects aged 60-80 and young and middle-aged subjects aged 18 to 59 years, 3. The subjects can and are willing to comply with the requirements of the clinical trial protocol, complete the 12-month study follow-up and sign the informed consent, 4. HBsAg, anti HCV, HIV and TPHA screening were negative, 5. The new crown RNA test was negative, 6. Axillary body temperature <=37.0 degree C.

1. The new crown vaccine is planned. 2. Elderly subjects aged 60-80 and young and middle-aged subjects aged 18 to 59 years, 3. The subjects can and are willing to comply with the requirements of the clinical trial protocol, complete the 12-month study follow-up and sign the informed consent, 4. HBsAg, anti HCV, HIV and TPHA screening were negative, 5. The new crown RNA test was negative, 6. Axillary body temperature <=37.0 degree C.

1. The new crown vaccine is planned. 2. Elderly subjects aged 60-80 and young and middle-aged subjects aged 18 to 59 years, 3. The subjects can and are willing to comply with the requirements of the clinical trial protocol, complete the 12-month study follow-up and sign the informed consent, 4. HBsAg, anti HCV, HIV and TPHA screening were negative, 5. The new crown RNA test was negative, 6. Axillary body temperature <=37.0 degree C.