1. Healthy control group: no history of hepatitis, no history of liver cirrhosis, no history of liver cancer, received full-course vaccination against COVID-19. 2. Patients with chronic liver disease: patients with chronic liver disease diagnosed clinically or pathologically, receive full-course COVID-19 vaccination.

1. Healthy control group: no history of hepatitis, no history of liver cirrhosis, no history of liver cancer, received full-course vaccination against COVID-19. 2. Patients with chronic liver disease: patients with chronic liver disease diagnosed clinically or pathologically, receive full-course COVID-19 vaccination.

1. Healthy control group: no history of hepatitis, no history of liver cirrhosis, no history of liver cancer, COVID-19 was vaccinated throughout the course, 2. Patients with chronic liver disease: patients with chronic liver disease diagnosed clinically or pathologically, received COVID-19 vaccination

1. Healthy control group: no history of hepatitis, no history of liver cirrhosis, no history of liver cancer, COVID-19 was vaccinated throughout the course, 2. Patients with chronic liver disease: patients with chronic liver disease diagnosed clinically or pathologically, received COVID-19 vaccination