- Age range: Healthy subjects aged 18 years old and above - By asking for medical history and physical examination, the investigator judged that the health condition is well. - Female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test), and do not plan to become pregnant within the first 3 months after enrolment. Effective contraceptive measures have been taken within 2 weeks before inclusion and continued for at least three months after last dose. - During the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. - With self-ability to understand the research procedures, with informed consent, voluntarily sign an informed consent form, and be able to comply with the requirements of the clinical study protocol.

- Age range: Healthy subjects aged 18 years old and above - By asking for medical history and physical examination, the investigator judged that the health condition is well. - Female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test), and do not plan to become pregnant within the first 3 months after enrolment. Effective contraceptive measures have been taken within 2 weeks before inclusion and continued for at least three months after last dose. - During the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. - With self-ability to understand the research procedures, with informed consent, voluntarily sign an informed consent form, and be able to comply with the requirements of the clinical study protocol.