* shock or multiorgan disfunction that require continous vital signs monitorization * punctuation equal or more than 7 in the national early warning score (news) - 2 scale. * condition that seriously affects the patient survival expectancies, including any active cancer, hemorragia, any blood disease or severe malnutrition. * pregnant women or breast feeding. * advanced hearth failure. * vih/aids. * bacterial or fungical uncontroled infection. * permanente use of immunosupresants or have had received an organ trasnplanted in the past six months. * imposibility to sign the informent consent format. * patients involved in another clinical trial with drugs or interventions.

* shock or multiorgan disfunction that require continous vital signs monitorization * punctuation equal or more than 7 in the national early warning score (news) - 2 scale. * condition that seriously affects the patient survival expectancies, including any active cancer, hemorragia, any blood disease or severe malnutrition. * pregnant women or breast feeding. * advanced hearth failure. * vih/aids. * bacterial or fungical uncontroled infection. * permanente use of immunosupresants or have had received an organ trasnplanted in the past six months. * imposibility to sign the informent consent format. * patients involved in another clinical trial with drugs or interventions.

- shock or multiorgan disfunction that require continous vital signs monitorization - punctuation equal or more than 7 in the national early warning score (news) - 2 scale. - condition that seriously affects the patient survival expectancies, including any active cancer, hemorragia, any blood disease or severe malnutrition. - pregnant women or breast feeding. - advanced hearth failure. - vih/aids. - bacterial or fungical uncontroled infection. - permanente use of immunosupresants or have had received an organ trasnplanted in the past six months. - imposibility to sign the informent consent format. - patients involved in another clinical trial with drugs or interventions.

- shock or multiorgan disfunction that require continous vital signs monitorization - punctuation equal or more than 7 in the national early warning score (news) - 2 scale. - condition that seriously affects the patient survival expectancies, including any active cancer, hemorragia, any blood disease or severe malnutrition. - pregnant women or breast feeding. - advanced hearth failure. - vih/aids. - bacterial or fungical uncontroled infection. - permanente use of immunosupresants or have had received an organ trasnplanted in the past six months. - imposibility to sign the informent consent format. - patients involved in another clinical trial with drugs or interventions.