Plasma donor: be between 18 and 60 years old, be male or a female that has never been pregnant, weight at least 60 kg, have SARS-CoV-2 infection confirmed by positive RT-PCR, be eligible for blood donation, according to the appropriate Brazilian law (Seção II da Portaria de Consolidação n.5, de 28 de setembro de 2017), agree to participate in the study and sign the informed consent form(s), have no Covid-19 symptoms for 14-27 days, in which case a new RT-PCR test from a nasopharyngeal or oropharyngeal swab has to be negative OR have no Covid-19 symptoms for 28 days or more, in which case no additional tests are necessary, have a positive result on a SAR-CoV-2 IgG test. Plasma transfusion receptor: be 18 years or older, have been admitted to a hospital to treat moderate Covid-19, defined as compatible clinical characteristics, such as dyspnea and/or fever and/or cough plus chest computed tomography with bilateral ground glass opacities, have SARS-CoV-2 infection confirmed by nasopharyngeal and/or oropharyngeal swab PCR or serological assay that detects IgM or SARS-CoV-2 antigen, have Covid-19 symptoms for no more than 10 days.

Plasma donor: be between 18 and 60 years old, be male or a female that has never been pregnant, weight at least 60 kg, have SARS-CoV-2 infection confirmed by positive RT-PCR, be eligible for blood donation, according to the appropriate Brazilian law (Seção II da Portaria de Consolidação n.5, de 28 de setembro de 2017), agree to participate in the study and sign the informed consent form(s), have no Covid-19 symptoms for 14-27 days, in which case a new RT-PCR test from a nasopharyngeal or oropharyngeal swab has to be negative OR have no Covid-19 symptoms for 28 days or more, in which case no additional tests are necessary, have a positive result on a SAR-CoV-2 IgG test. Plasma transfusion receptor: be 18 years or older, have been admitted to a hospital to treat moderate Covid-19, defined as compatible clinical characteristics, such as dyspnea and/or fever and/or cough plus chest computed tomography with bilateral ground glass opacities, have SARS-CoV-2 infection confirmed by nasopharyngeal and/or oropharyngeal swab PCR or serological assay that detects IgM or SARS-CoV-2 antigen, have Covid-19 symptoms for no more than 10 days.