Created at Source Raw Value Validated value
Dec. 10, 2021, 2 p.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "A pulmonary rehabilitation (PR) program associated with the use of noninvasive ventilation (NIV) will be conducted in individuals with COVID-19 after the severe form (post-COVID-19 syndrome). 100 individuals with the post-COVID-19 syndrome with dyspnea symptoms through the modified Medical Research Council (mMRC) level II and III. 50 volunteers will be allocated to the pulmonary rehabilitation group and 50 volunteers to the rehabilitation + NIV group will be recruited. In addition; a subgroup analysis will be performed with 25 volunteers from the early rehabilitation group + NIV; 25 volunteers from the early rehabilitation group without NIV; 25 volunteers from the late rehabilitation group + NIV; and 25 volunteers from the late rehabilitation group without NIV. The PR will be performed 3 times a week for 8 weeks and will consist of aerobic training; resistance training; and inspiratory muscle training (IMT). All procedures will be performed by trained and harmonized members in the trial procedures; and always under the supervision of the principal investigator. The aerobic training will be carried out on a treadmill. In the first two weeks; individuals will start training with a speed that reaches 50% of the maximum HR achieved in the cardiopulmonary test (CPX) and/or perceived exertion of 3 on the Borg CR10 scale. In this phase; the volunteer will do 5 minutes of warm-up at minimum load on the treadmill; 15 minutes of constant load; and 10 minutes of active recovery with minimum speed on the treadmill. After 2 weeks; the individuals will perform the training with a speed that reaches 70% of the maximum HR reached in CPX and/or perceived exertion of 4 \u2013 5 on the Borg CR 10 scale. In this phase; the volunteer will do 5 minutes of warm-up in minimum treadmill load; 30 min;E02.760.169.063.500.185;E02.041.625.591", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 1043, "treatment_name": "Pulmonary rehabilitation", "treatment_type": "Rehabilitation", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 1674, "treatment_name": "Non invasive ventilation+pulmonary rehabilitation", "treatment_type": "Respiratory support+rehabilitation", "pharmacological_treatment": "Non pharmacological treatment"}]