inclusion criteria: 1. provided informed consent (emergency consent according to local regulations where approved) 2. age 18 to 75 years (inclusive) 3. admitted to an intensive care unit 4. treatment with high flow nasal oxygen, non-invasive ventilation or invasive mechanical ventilation for acute respiratory failure caused by covid-19 for less than 48 hours 5. a pao2:fio2 ratio of \<200mmhg (\<26.7kpa) with a fio2 ≥0.6 6. confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria

inclusion criteria: 1. provided informed consent (emergency consent according to local regulations where approved) 2. age 18 to 75 years (inclusive) 3. admitted to an intensive care unit 4. treatment with high flow nasal oxygen, non-invasive ventilation or invasive mechanical ventilation for acute respiratory failure caused by covid-19 for less than 48 hours 5. a pao2:fio2 ratio of \<200mmhg (\<26.7kpa) with a fio2 ≥0.6 6. confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria

inclusion criteria: provided informed consent (emergency consent according to local regulations where approved) age 18 to 75 years (inclusive) admitted to an intensive care unit treatment with high flow nasal oxygen, non-invasive ventilation or invasive mechanical ventilation for acute respiratory failure caused by covid-19 for less than 48 hours a pao2:fio2 ratio of <200mmhg (<26.7kpa) with a fio2 ≥0.6 confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria

inclusion criteria: provided informed consent (emergency consent according to local regulations where approved) age 18 to 75 years (inclusive) admitted to an intensive care unit treatment with high flow nasal oxygen, non-invasive ventilation or invasive mechanical ventilation for acute respiratory failure caused by covid-19 for less than 48 hours a pao2:fio2 ratio of <200mmhg (<26.7kpa) with a fio2 ≥0.6 confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria

inclusion criteria: 1. provided informed consent (emergency consent according to local regulations where approved) 2. age 18 to 75 years (inclusive) 3. admitted to an intensive care unit 4. treatment with high flow nasal oxygen, non-invasive ventilation or invasive mechanical ventilation for acute respiratory failure caused by covid-19 for less than 48 hours 5. a pao2:fio2 ratio of <200mmhg (<26.7kpa) with a fio2 ≥0.6 6. confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria

inclusion criteria: 1. provided informed consent (emergency consent according to local regulations where approved) 2. age 18 to 75 years (inclusive) 3. admitted to an intensive care unit 4. treatment with high flow nasal oxygen, non-invasive ventilation or invasive mechanical ventilation for acute respiratory failure caused by covid-19 for less than 48 hours 5. a pao2:fio2 ratio of <200mmhg (<26.7kpa) with a fio2 ≥0.6 6. confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria

inclusion criteria: 1. provided informed consent (emergency consent according to local regulations where approved) 2. age 18 to 75 years (inclusive) 3. invasive mechanical ventilation (respiratory support using a mechanical ventilator delivered via an endotracheal tube or tracheostomy) for acute respiratory failure caused by covid-19 for less than 48 hours 4. a pao2:fio2 ratio of <200mmhg (<26.7kpa) 5. confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria

inclusion criteria: 1. provided informed consent (emergency consent according to local regulations where approved) 2. age 18 to 75 years (inclusive) 3. invasive mechanical ventilation (respiratory support using a mechanical ventilator delivered via an endotracheal tube or tracheostomy) for acute respiratory failure caused by covid-19 for less than 48 hours 4. a pao2:fio2 ratio of <200mmhg (<26.7kpa) 5. confirmed laboratory diagnosis of covid-19 within 7 days of meeting screening criteria