Progress to death is imminent and unavoidable in the opinion of the investigator, Participating in other clinical trials (except in COVID-19 antiviral drug trials), Any condition that in the view of the screening physician suggests that the patient is unable to comply with study procedures, Subjects treated with immunosuppressive drugs, HIV infection, Pregnant women or breastfeeding mothers, Estimated glomerular filtration rate less than 30ml/min, Severe liver disfunction (Child-Pugh score C), Medical history of oral glucocorticoid treatment (Exception is COVID-19 dexamethasone treatment not exceeding 10mg/day).

Progress to death is imminent and unavoidable in the opinion of the investigator, Participating in other clinical trials (except in COVID-19 antiviral drug trials), Any condition that in the view of the screening physician suggests that the patient is unable to comply with study procedures, Subjects treated with immunosuppressive drugs, HIV infection, Pregnant women or breastfeeding mothers, Estimated glomerular filtration rate less than 30ml/min, Severe liver disfunction (Child-Pugh score C), Medical history of oral glucocorticoid treatment (Exception is COVID-19 dexamethasone treatment not exceeding 10mg/day).