1. 18 years old or more 2. negative for blood SARS-CoV-2 antibody 3. negative for nasopharynx PCR for SARS-CoV-2 4. Negative urine pregnancy test (in case of potential of pregnancy) 5. No history of a severe allergic reaction to the prior vaccine. 6. No fever nor history of fever within 14 days. 7. No symptom of respiratory tract infection within 14 days. 8. ECOG 0,1 9. sign informed consent to the study.

1. 18 years old or more 2. negative for blood SARS-CoV-2 antibody 3. negative for nasopharynx PCR for SARS-CoV-2 4. Negative urine pregnancy test (in case of potential of pregnancy) 5. No history of a severe allergic reaction to the prior vaccine. 6. No fever nor history of fever within 14 days. 7. No symptom of respiratory tract infection within 14 days. 8. ECOG 0,1 9. sign informed consent to the study.