1. prior COVID-19 vaccination. 2. Vaccination with any vaccines within 30 days 3. administration of steroid or receive immunoglobulins within 30 days 4. Receive immunosuppression agent within 30 days. 5. pregnancy. 6. lactation. 7. acute coronary syndrome in the past year. 8. Acute stroke in the past year. 9. Splenectomy 10. active chronic infectious disease.

1. prior COVID-19 vaccination. 2. Vaccination with any vaccines within 30 days 3. administration of steroid or receive immunoglobulins within 30 days 4. Receive immunosuppression agent within 30 days. 5. pregnancy. 6. lactation. 7. acute coronary syndrome in the past year. 8. Acute stroke in the past year. 9. Splenectomy 10. active chronic infectious disease.