1. Obtunded <br/ >2. The attending clinician is not committed to patient receiving mechanical ventilatory support <br/ >3. In the opinion of the treating clinician the patient is in respiratory distress and is eminently <br/ >requiring escalation of treatment including intubation and mechanical ventilation <br/ >4. Currently receiving either CPAP, BiPAP, high flow nasal prongs or mechanical ventilation <br/ >5. Participants usually on home ventilation (either CPAP or BiPAP) <br/ >6. Previous participation in PROVE trial <br/ >7. Known or suspected pregnancy <br/ >8. Enrolment in the study is not in the best interest of the patient as deemed by the treating clinician

1. Obtunded <br/ >2. The attending clinician is not committed to patient receiving mechanical ventilatory support <br/ >3. In the opinion of the treating clinician the patient is in respiratory distress and is eminently <br/ >requiring escalation of treatment including intubation and mechanical ventilation <br/ >4. Currently receiving either CPAP, BiPAP, high flow nasal prongs or mechanical ventilation <br/ >5. Participants usually on home ventilation (either CPAP or BiPAP) <br/ >6. Previous participation in PROVE trial <br/ >7. Known or suspected pregnancy <br/ >8. Enrolment in the study is not in the best interest of the patient as deemed by the treating clinician

N/A

N/A

1. Obtunded <br/ >2. The attending clinician is not committed to patient receiving mechanical ventilatory support <br/ >3. In the opinion of the treating clinician the patient is in respiratory distress and is eminently <br/ >requiring escalation of treatment including intubation and mechanical ventilation <br/ >4. Currently receiving either CPAP, BiPAP, high flow nasal prongs or mechanical ventilation <br/ >5. Participants usually on home ventilation (either CPAP or BiPAP) <br/ >6. Previous participation in PROVE trial <br/ >7. Known or suspected pregnancy <br/ >8. Enrolment in the study is not in the best interest of the patient as deemed by the treating clinician

1. Obtunded <br/ >2. The attending clinician is not committed to patient receiving mechanical ventilatory support <br/ >3. In the opinion of the treating clinician the patient is in respiratory distress and is eminently <br/ >requiring escalation of treatment including intubation and mechanical ventilation <br/ >4. Currently receiving either CPAP, BiPAP, high flow nasal prongs or mechanical ventilation <br/ >5. Participants usually on home ventilation (either CPAP or BiPAP) <br/ >6. Previous participation in PROVE trial <br/ >7. Known or suspected pregnancy <br/ >8. Enrolment in the study is not in the best interest of the patient as deemed by the treating clinician