1. Age <18 years <br/ >2. Mechanical ventilation for more than 7 days. <br/ >3. Mean Arterial Pressure < 65 mm Hg with use of pressor per ICU protocol <br/ >4. Irreversible condition (other than COVID-19) with projected fatal course <br/ >5. Requirement of Extracorporeal membrane oxygenation (ECMO) <br/ >6. Current or recent (within 30 d) enrolment in another investigational trial of anti-IL6 drug, <br/ >7. Active diagnosis of Acquired immune deficiency syndrome, <br/ >8. Transplant patients currently immunosuppressed, <br/ >9. Chemotherapy-induced neutropenia (granulocyte count <1000/mm3), <br/ >10. Cardiogenic shock, congestive heart failure - NYHA Class 3 or 4, <br/ >11. Recent myocardial infarction - within last 6 months and troponin > 0.5 <br/ >12. Anuria (urine output < 50 ml/d) or other signs of multi-organ failure <br/ >13. Severe liver disease with portal hypertension, <br/ >14. Recent stroke or head trauma within last 12 months <br/ >15. Increased intracranial pressure, or other serious neurologic disorder, <br/ >16. Liquid diarrhea more than 3/day, defined as more than 3 non-bloody watery stools within a 24-hour period, requiring additional fluid and electrolyte supplementation <br/ >17. Pregnant or lactating women

1. Age <18 years <br/ >2. Mechanical ventilation for more than 7 days. <br/ >3. Mean Arterial Pressure < 65 mm Hg with use of pressor per ICU protocol <br/ >4. Irreversible condition (other than COVID-19) with projected fatal course <br/ >5. Requirement of Extracorporeal membrane oxygenation (ECMO) <br/ >6. Current or recent (within 30 d) enrolment in another investigational trial of anti-IL6 drug, <br/ >7. Active diagnosis of Acquired immune deficiency syndrome, <br/ >8. Transplant patients currently immunosuppressed, <br/ >9. Chemotherapy-induced neutropenia (granulocyte count <1000/mm3), <br/ >10. Cardiogenic shock, congestive heart failure - NYHA Class 3 or 4, <br/ >11. Recent myocardial infarction - within last 6 months and troponin > 0.5 <br/ >12. Anuria (urine output < 50 ml/d) or other signs of multi-organ failure <br/ >13. Severe liver disease with portal hypertension, <br/ >14. Recent stroke or head trauma within last 12 months <br/ >15. Increased intracranial pressure, or other serious neurologic disorder, <br/ >16. Liquid diarrhea more than 3/day, defined as more than 3 non-bloody watery stools within a 24-hour period, requiring additional fluid and electrolyte supplementation <br/ >17. Pregnant or lactating women

N/A

N/A

1. Age <18 years <br/ >2. Mechanical ventilation for more than 7 days. <br/ >3. Mean Arterial Pressure < 65 mm Hg with use of pressor per ICU protocol <br/ >4. Irreversible condition (other than COVID-19) with projected fatal course <br/ >5. Requirement of Extracorporeal membrane oxygenation (ECMO) <br/ >6. Current or recent (within 30 d) enrolment in another investigational trial of anti-IL6 drug, <br/ >7. Active diagnosis of Acquired immune deficiency syndrome, <br/ >8. Transplant patients currently immunosuppressed, <br/ >9. Chemotherapy-induced neutropenia (granulocyte count <1000/mm3), <br/ >10. Cardiogenic shock, congestive heart failure - NYHA Class 3 or 4, <br/ >11. Recent myocardial infarction - within last 6 months and troponin > 0.5 <br/ >12. Anuria (urine output < 50 ml/d) or other signs of multi-organ failure <br/ >13. Severe liver disease with portal hypertension, <br/ >14. Recent stroke or head trauma within last 12 months <br/ >15. Increased intracranial pressure, or other serious neurologic disorder, <br/ >16. Liquid diarrhea more than 3/day, defined as more than 3 non-bloody watery stools within a 24-hour period, requiring additional fluid and electrolyte supplementation <br/ >17. Pregnant or lactating women

1. Age <18 years <br/ >2. Mechanical ventilation for more than 7 days. <br/ >3. Mean Arterial Pressure < 65 mm Hg with use of pressor per ICU protocol <br/ >4. Irreversible condition (other than COVID-19) with projected fatal course <br/ >5. Requirement of Extracorporeal membrane oxygenation (ECMO) <br/ >6. Current or recent (within 30 d) enrolment in another investigational trial of anti-IL6 drug, <br/ >7. Active diagnosis of Acquired immune deficiency syndrome, <br/ >8. Transplant patients currently immunosuppressed, <br/ >9. Chemotherapy-induced neutropenia (granulocyte count <1000/mm3), <br/ >10. Cardiogenic shock, congestive heart failure - NYHA Class 3 or 4, <br/ >11. Recent myocardial infarction - within last 6 months and troponin > 0.5 <br/ >12. Anuria (urine output < 50 ml/d) or other signs of multi-organ failure <br/ >13. Severe liver disease with portal hypertension, <br/ >14. Recent stroke or head trauma within last 12 months <br/ >15. Increased intracranial pressure, or other serious neurologic disorder, <br/ >16. Liquid diarrhea more than 3/day, defined as more than 3 non-bloody watery stools within a 24-hour period, requiring additional fluid and electrolyte supplementation <br/ >17. Pregnant or lactating women