* has pre-existing medical conditions of any nature which are immediately pre-terminal such as death or limitation of life-sustaining therapy is expected to be imminent * requires or is expected to require invasive mechanical ventilation * requires or is expected to require noninvasive mechanical ventilation * has any issue which would prohibit them from effective use of the frespaciguat inhaler * hypoxemia which is explained by any condition other than covid-19, example, preexisting cardiac or pulmonary disease * has severe hepatic impairment (meets child-pugh class c criteria) * has severe renal impairment and/or requirement for renal dialysis

* has pre-existing medical conditions of any nature which are immediately pre-terminal such as death or limitation of life-sustaining therapy is expected to be imminent * requires or is expected to require invasive mechanical ventilation * requires or is expected to require noninvasive mechanical ventilation * has any issue which would prohibit them from effective use of the frespaciguat inhaler * hypoxemia which is explained by any condition other than covid-19, example, preexisting cardiac or pulmonary disease * has severe hepatic impairment (meets child-pugh class c criteria) * has severe renal impairment and/or requirement for renal dialysis

* has pre-existing medical conditions of any nature which are immediately pre-terminal such as death or limitation of life-sustaining therapy is expected to be imminent * requires or is expected to require invasive mechanical ventilation * requires or is expected to require noninvasive mechanical ventilation * has any issue which would prohibit them from effective use of the mk-5475 inhaler * hypoxemia which is explained by any condition other than covid-19, example, preexisting cardiac or pulmonary disease * has severe hepatic impairment (meets child-pugh class c criteria) * has severe renal impairment and/or requirement for renal dialysis

* has pre-existing medical conditions of any nature which are immediately pre-terminal such as death or limitation of life-sustaining therapy is expected to be imminent * requires or is expected to require invasive mechanical ventilation * requires or is expected to require noninvasive mechanical ventilation * has any issue which would prohibit them from effective use of the mk-5475 inhaler * hypoxemia which is explained by any condition other than covid-19, example, preexisting cardiac or pulmonary disease * has severe hepatic impairment (meets child-pugh class c criteria) * has severe renal impairment and/or requirement for renal dialysis

- has pre-existing medical conditions of any nature which are immediately pre-terminal such as death or limitation of life-sustaining therapy is expected to be imminent - requires or is expected to require invasive mechanical ventilation - requires or is expected to require noninvasive mechanical ventilation - has any issue which would prohibit them from effective use of the mk-5475 inhaler - hypoxemia which is explained by any condition other than covid-19, example, preexisting cardiac or pulmonary disease - has severe hepatic impairment (meets child-pugh class c criteria) - has severe renal impairment and/or requirement for renal dialysis

- has pre-existing medical conditions of any nature which are immediately pre-terminal such as death or limitation of life-sustaining therapy is expected to be imminent - requires or is expected to require invasive mechanical ventilation - requires or is expected to require noninvasive mechanical ventilation - has any issue which would prohibit them from effective use of the mk-5475 inhaler - hypoxemia which is explained by any condition other than covid-19, example, preexisting cardiac or pulmonary disease - has severe hepatic impairment (meets child-pugh class c criteria) - has severe renal impairment and/or requirement for renal dialysis