1. Having a history of COVID-19 or a positive nucleic acid test for COVID-19, 2. Having a history or a family history of allergy, convulsion, epilepsy, brain disease, or mental illness, 3. Being allergic to any component of vaccines, or having a history of severe allergic reaction to any vaccine, 4. Having immunodeficiency disorder, during treatment of malignant tumor, having immunodeficiency induced by immunosuppressants (oral steroid hormones) or HIV, or having a family member with close contact who suffers from congenital immune disorder, 5. Having injection of non-specific immunoglobulin within 1 month prior to enrollment, 6. Having acute febrile illness or communicable disease, 7. Having a history of confirmed thrombocytopenia or other coagulation disorders, which may cause contraindications for a subcutaneous injection, 8. Having severe chronic disease or acute exacerbation of chronic disease.Through lifestyle adjustment and/or drug therapy, those with systolic blood pressure >=160 mmHg or diastolic blood pressure >=100 mmH on the day of vaccination, and those with lifestyle adjustment and/or drug therapy, those whose fasting blood glucose is still >13.9 mmol/L on the day of vaccination , In the period of acute complications of diabetes (ketoacidosis, hypertonic state, lactic acidosis), or those who have recovered from the above complications for less than 2 weeks, 9. Having various infectious, pyogenic, or allergic skin diseases, 10. Women in pregnancy or lactation or participants who plan for a baby within 3 months after vaccination should delay the vaccination, 11. Having any condition that may affect trial assessment as determined by researchers.

1. Having a history of COVID-19 or a positive nucleic acid test for COVID-19, 2. Having a history or a family history of allergy, convulsion, epilepsy, brain disease, or mental illness, 3. Being allergic to any component of vaccines, or having a history of severe allergic reaction to any vaccine, 4. Having immunodeficiency disorder, during treatment of malignant tumor, having immunodeficiency induced by immunosuppressants (oral steroid hormones) or HIV, or having a family member with close contact who suffers from congenital immune disorder, 5. Having injection of non-specific immunoglobulin within 1 month prior to enrollment, 6. Having acute febrile illness or communicable disease, 7. Having a history of confirmed thrombocytopenia or other coagulation disorders, which may cause contraindications for a subcutaneous injection, 8. Having severe chronic disease or acute exacerbation of chronic disease.Through lifestyle adjustment and/or drug therapy, those with systolic blood pressure >=160 mmHg or diastolic blood pressure >=100 mmH on the day of vaccination, and those with lifestyle adjustment and/or drug therapy, those whose fasting blood glucose is still >13.9 mmol/L on the day of vaccination , In the period of acute complications of diabetes (ketoacidosis, hypertonic state, lactic acidosis), or those who have recovered from the above complications for less than 2 weeks, 9. Having various infectious, pyogenic, or allergic skin diseases, 10. Women in pregnancy or lactation or participants who plan for a baby within 3 months after vaccination should delay the vaccination, 11. Having any condition that may affect trial assessment as determined by researchers.

1. Having a history of COVID-19 or a positive nucleic acid test for COVID-19, 2. Having a history or a family history of allergy, convulsion, epilepsy, brain disease, or mental illness, 3. Being allergic to any component of vaccines, or having a history of severe allergic reaction to any vaccine, 4. Having immunodeficiency disorder, during treatment of malignant tumor, having immunodeficiency induced by immunosuppressants (oral steroid hormones) or HIV, or having a family member with close contact who suffers from congenital immune disorder, 5. Having injection of non-specific immunoglobulin within 1 month prior to enrollment, 6. Having acute febrile illness or communicable disease, 7. Having a history of confirmed thrombocytopenia or other coagulation disorders, which may cause contraindications for a subcutaneous injection, 8. Having severe chronic disease or acute exacerbation of chronic disease.Through lifestyle adjustment and/or drug therapy, those with systolic blood pressure =160 mmHg or diastolic blood pressure =100 mmH on the day of vaccination, and those with lifestyle adjustment and/or drug therapy, those whose fasting blood glucose is still >13.9 mmol/L on the day of vaccination , In the period of acute complications of diabetes (ketoacidosis, hypertonic state, lactic acidosis), or those who have recovered from the above complications for less than 2 weeks, 9. Having various infectious, pyogenic, or allergic skin diseases, 10. Women in pregnancy or lactation or participants who plan for a baby within 3 months after vaccination should delay the vaccination, 11. Having any condition that may affect trial assessment as determined by researchers.

1. Having a history of COVID-19 or a positive nucleic acid test for COVID-19, 2. Having a history or a family history of allergy, convulsion, epilepsy, brain disease, or mental illness, 3. Being allergic to any component of vaccines, or having a history of severe allergic reaction to any vaccine, 4. Having immunodeficiency disorder, during treatment of malignant tumor, having immunodeficiency induced by immunosuppressants (oral steroid hormones) or HIV, or having a family member with close contact who suffers from congenital immune disorder, 5. Having injection of non-specific immunoglobulin within 1 month prior to enrollment, 6. Having acute febrile illness or communicable disease, 7. Having a history of confirmed thrombocytopenia or other coagulation disorders, which may cause contraindications for a subcutaneous injection, 8. Having severe chronic disease or acute exacerbation of chronic disease.Through lifestyle adjustment and/or drug therapy, those with systolic blood pressure =160 mmHg or diastolic blood pressure =100 mmH on the day of vaccination, and those with lifestyle adjustment and/or drug therapy, those whose fasting blood glucose is still >13.9 mmol/L on the day of vaccination , In the period of acute complications of diabetes (ketoacidosis, hypertonic state, lactic acidosis), or those who have recovered from the above complications for less than 2 weeks, 9. Having various infectious, pyogenic, or allergic skin diseases, 10. Women in pregnancy or lactation or participants who plan for a baby within 3 months after vaccination should delay the vaccination, 11. Having any condition that may affect trial assessment as determined by researchers.