1. Individuals previously vaccinated with a vaccine candidate or SARS-CoV-2 vaccine. 2. Documented history of previous COVID-19 infection by medical questioning. 3. Allergy to any of the components of the vaccine. 4. Administration of immunosuppressants in the 30 days prior to vaccination 5. Decompensated chronic diseases that limit vaccination. 6. Pregnancy, puerperium and lactation. 7. Acute illness that contraindicates vaccination. 8. HIV positive subject with detectable viral load, opportunistic disease or CD4 + count less than 200 copies (according to the last follow-up check of the patient).

1. Individuals previously vaccinated with a vaccine candidate or SARS-CoV-2 vaccine. 2. Documented history of previous COVID-19 infection by medical questioning. 3. Allergy to any of the components of the vaccine. 4. Administration of immunosuppressants in the 30 days prior to vaccination 5. Decompensated chronic diseases that limit vaccination. 6. Pregnancy, puerperium and lactation. 7. Acute illness that contraindicates vaccination. 8. HIV positive subject with detectable viral load, opportunistic disease or CD4 + count less than 200 copies (according to the last follow-up check of the patient).