Study participant (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. Understands and agrees to comply with planned study procedures. Agrees to the collection of OP swabs and venous blood per protocol. Male or non-pregnant female adult =18 years of age at time of enrolment. Laboratory-confirmed SARS-CoV-2 infection as determined by PCR nasopharyngeal swab. Illness of any duration, and at least one of the follow ing: Clinical assessment (evidence of rales/crackles on exam) or Requiring mechanical ventilation and/or supplemental oxygen. Creatinine = 110 umol/L, creatinine clearance rate (EGFR) = 60 ml / min / 1.73m2, AST and ALT = 5 × ULN, TBIL = 2 × ULN, A Normal ECG Baseline result, which is maintained throughout the study.

Study participant (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. Understands and agrees to comply with planned study procedures. Agrees to the collection of OP swabs and venous blood per protocol. Male or non-pregnant female adult =18 years of age at time of enrolment. Laboratory-confirmed SARS-CoV-2 infection as determined by PCR nasopharyngeal swab. Illness of any duration, and at least one of the follow ing: Clinical assessment (evidence of rales/crackles on exam) or Requiring mechanical ventilation and/or supplemental oxygen. Creatinine = 110 umol/L, creatinine clearance rate (EGFR) = 60 ml / min / 1.73m2, AST and ALT = 5 × ULN, TBIL = 2 × ULN, A Normal ECG Baseline result, which is maintained throughout the study.