1. Incidence of =1 solicited systemic reaction measured using an electronic diary completed by participants in the 7 days following visit 1. Solicited systemic adverse events include fever; feverishness; chills; joint pains; muscle pains; fatigue; headache; malaise; nausea; vomiting; and diarrhoea.

1. Incidence of =1 solicited systemic reaction measured using an electronic diary completed by participants in the 7 days following visit 1. Solicited systemic adverse events include fever; feverishness; chills; joint pains; muscle pains; fatigue; headache; malaise; nausea; vomiting; and diarrhoea.