1. Adults of 18 years of age, and older, 2. Able and willing (in the Investigators opinion) to comply with all study requirements, 3. Willing to allow the investigators to discuss the volunteers medical history with their General, 4. Practitioner/personal doctor and access all medical records when relevant to study procedures, 5. Healthy adults, or stable-healthy adults who may have a pre-existing medical condition that does not meet any exclusion criteria. A stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during the 3 months before enrollment [4], 6. For females of childbearing potential only, willingness to practice continuous effective contraception (see glossary) for 30 days prior to enrollment in the study, for 90 days after receiving vaccination during the study, and have a negative pregnancy test on the day(s) of screening/ vaccination (Day 0), 7. Males participating in this study who are involved in heterosexual sexual activity must agree to practice adequate contraception (see glossary) and refrain from donating sperm for 90 days after receiving the study vaccination, 8. Agreement to refrain from blood donation during the study, 9. Provide written informed consent.

1. Adults of 18 years of age, and older, 2. Able and willing (in the Investigators opinion) to comply with all study requirements, 3. Willing to allow the investigators to discuss the volunteers medical history with their General, 4. Practitioner/personal doctor and access all medical records when relevant to study procedures, 5. Healthy adults, or stable-healthy adults who may have a pre-existing medical condition that does not meet any exclusion criteria. A stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during the 3 months before enrollment [4], 6. For females of childbearing potential only, willingness to practice continuous effective contraception (see glossary) for 30 days prior to enrollment in the study, for 90 days after receiving vaccination during the study, and have a negative pregnancy test on the day(s) of screening/ vaccination (Day 0), 7. Males participating in this study who are involved in heterosexual sexual activity must agree to practice adequate contraception (see glossary) and refrain from donating sperm for 90 days after receiving the study vaccination, 8. Agreement to refrain from blood donation during the study, 9. Provide written informed consent.