1. Subjects with history of COVID-19, asymptomatic SARS-CoV-2 infection or pre-existing antibodies to SARS-CoV-2 2. Previous severe reaction or allergy to any components in the COVID-19 vaccine 3. History of hospitalization within the past one month before injection. 4. Serious underlying medical condition (e.g., immunosuppressive disease or receiving immunosuppressive therapy, human immunodeficiency virus (HIV) infection) 5. Pregnant women, lactating women or women who are planning to become pregnant

1. Subjects with history of COVID-19, asymptomatic SARS-CoV-2 infection or pre-existing antibodies to SARS-CoV-2 2. Previous severe reaction or allergy to any components in the COVID-19 vaccine 3. History of hospitalization within the past one month before injection. 4. Serious underlying medical condition (e.g., immunosuppressive disease or receiving immunosuppressive therapy, human immunodeficiency virus (HIV) infection) 5. Pregnant women, lactating women or women who are planning to become pregnant