1. Individuals previously vaccinated with a vaccine candidate or SARS-CoV-2 vaccine. 2. Documented history of previous COVID-19 infection as a result of medical questioning. 3. Allergy to any of the components of the vaccine. 4. Administration of immunomodulators in the 30 days prior to vaccination. 5. Decompensated chronic diseases that limit vaccination. 6. Pregnancy, childbirth and the puerperium. 7. Acute illness that contraindicates vaccination 8. HIV subjects with detectable viral load, history of opportunistic infection or CD4 less than 200 copies.

1. Individuals previously vaccinated with a vaccine candidate or SARS-CoV-2 vaccine. 2. Documented history of previous COVID-19 infection as a result of medical questioning. 3. Allergy to any of the components of the vaccine. 4. Administration of immunomodulators in the 30 days prior to vaccination. 5. Decompensated chronic diseases that limit vaccination. 6. Pregnancy, childbirth and the puerperium. 7. Acute illness that contraindicates vaccination 8. HIV subjects with detectable viral load, history of opportunistic infection or CD4 less than 200 copies.