Less than 40 years and older than 80 years <br/ >With severe COVID-19 symptomsrequiring immediate hospitalization <br/ >(Severe COVID-19: pneumonia with respiratory rate >30 <br/ >breaths/min, severe respiratory distress, SpO2 2 days ago <br/ >usingoropharyngeal/nasal swab RT-PCR for Sars-Co-V2 <br/ >History of cardiopulmonary resuscitation <br/ >Patient with a known history of DVT, PE, stroke, atrial <br/ >fibrillation,mechanical heart valve, recent stent placement or any <br/ >other cardiovascular event or any other condition for which the <br/ >patient is takingsystemic anticoagulation/antiplatelet therapy (LMWH, <br/ >coumadin, clopidogrel and/or other similar classes of therapy)prior to <br/ >study enrollment. <br/ >Patients on corticosteroids <br/ >Subjects having history of organ failure or conditions requiring ICU <br/ >monitoring and treatment, such as severe liver disease, severe renal <br/ >dysfunction, upper gastrointestinal hemorrhage, disseminated <br/ >intravascular coagulation or any other condition that in the PIâ??s <br/ >opinion makes the subject unfit to participate <br/ >Respiratory failure, ARDS or need of immediate mechanical <br/ >ventilation upon presentation <br/ >History of acute exacerbation of comorbidity like heart failure, <br/ >diabetic ketoacidosis, myocardial infection, major cardiac rhythm <br/ >disorder or any other condition that in the PIâ??s opinion makes the <br/ >subject unfit to participate <br/ >History of or current hepatic failure or severely compromised liver <br/ >function, or renal failure or having chronic kidney disease or acute <br/ >renal failure <br/ >History of or currently receiving treatment for an endocrine disorder <br/ >like hypothyroidism, hyperthyroidism that is likely to affect the basal <br/ >heart rate. <br/ >HIV, HBsAg, HCV positive <br/ >Any condition causing immunodeficiency <br/ >Systemic connective tissue disease or any autoimmune disease that <br/ >is likely to affect HS-CRP levels <br/ >History of epilepsy/epileptic fit/convulsions in last 6 months or <br/ >currently on treatment for it <br/ >History of or currently having malignancy and being treated for <br/ >it.exception histologically confirmed and cured carcinoma in situ <br/ >Hypersensitivity reaction to Study drug/active control <br/ >Any psychiatric issue for which the subject is currently undergoing <br/ >treatment <br/ >Any history of drug/alcohol dependence within 30 days of screening <br/ >or current drug/alcohol dependence <br/ >Inability to understand the requirements of the Research Protocol <br/ >and follow the research procedures. <br/ >Pregnant or lactating <br/ >Not willing to use adequate contraception during study duration <br/ >Participation in any other clinical study less than 3 months before the <br/ >start of the study. <br/ >

Less than 40 years and older than 80 years <br/ >With severe COVID-19 symptomsrequiring immediate hospitalization <br/ >(Severe COVID-19: pneumonia with respiratory rate >30 <br/ >breaths/min, severe respiratory distress, SpO2 2 days ago <br/ >usingoropharyngeal/nasal swab RT-PCR for Sars-Co-V2 <br/ >History of cardiopulmonary resuscitation <br/ >Patient with a known history of DVT, PE, stroke, atrial <br/ >fibrillation,mechanical heart valve, recent stent placement or any <br/ >other cardiovascular event or any other condition for which the <br/ >patient is takingsystemic anticoagulation/antiplatelet therapy (LMWH, <br/ >coumadin, clopidogrel and/or other similar classes of therapy)prior to <br/ >study enrollment. <br/ >Patients on corticosteroids <br/ >Subjects having history of organ failure or conditions requiring ICU <br/ >monitoring and treatment, such as severe liver disease, severe renal <br/ >dysfunction, upper gastrointestinal hemorrhage, disseminated <br/ >intravascular coagulation or any other condition that in the PIâ??s <br/ >opinion makes the subject unfit to participate <br/ >Respiratory failure, ARDS or need of immediate mechanical <br/ >ventilation upon presentation <br/ >History of acute exacerbation of comorbidity like heart failure, <br/ >diabetic ketoacidosis, myocardial infection, major cardiac rhythm <br/ >disorder or any other condition that in the PIâ??s opinion makes the <br/ >subject unfit to participate <br/ >History of or current hepatic failure or severely compromised liver <br/ >function, or renal failure or having chronic kidney disease or acute <br/ >renal failure <br/ >History of or currently receiving treatment for an endocrine disorder <br/ >like hypothyroidism, hyperthyroidism that is likely to affect the basal <br/ >heart rate. <br/ >HIV, HBsAg, HCV positive <br/ >Any condition causing immunodeficiency <br/ >Systemic connective tissue disease or any autoimmune disease that <br/ >is likely to affect HS-CRP levels <br/ >History of epilepsy/epileptic fit/convulsions in last 6 months or <br/ >currently on treatment for it <br/ >History of or currently having malignancy and being treated for <br/ >it.exception histologically confirmed and cured carcinoma in situ <br/ >Hypersensitivity reaction to Study drug/active control <br/ >Any psychiatric issue for which the subject is currently undergoing <br/ >treatment <br/ >Any history of drug/alcohol dependence within 30 days of screening <br/ >or current drug/alcohol dependence <br/ >Inability to understand the requirements of the Research Protocol <br/ >and follow the research procedures. <br/ >Pregnant or lactating <br/ >Not willing to use adequate contraception during study duration <br/ >Participation in any other clinical study less than 3 months before the <br/ >start of the study. <br/ >

N/A

N/A

Less than 40 years and older than 80 years <br/ > With severe COVID-19 symptomsrequiring immediate hospitalization <br/ > (Severe COVID-19: pneumonia with respiratory rate >30 <br/ > breaths/min, severe respiratory distress, SpO2 2 days ago <br/ > usingoropharyngeal/nasal swab RT-PCR for Sars-Co-V2 <br/ > History of cardiopulmonary resuscitation <br/ > Patient with a known history of DVT, PE, stroke, atrial <br/ > fibrillation,mechanical heart valve, recent stent placement or any <br/ > other cardiovascular event or any other condition for which the <br/ > patient is takingsystemic anticoagulation/antiplatelet therapy (LMWH, <br/ > coumadin, clopidogrel and/or other similar classes of therapy)prior to <br/ > study enrollment. <br/ > Patients on corticosteroids <br/ > Subjects having history of organ failure or conditions requiring ICU <br/ > monitoring and treatment, such as severe liver disease, severe renal <br/ > dysfunction, upper gastrointestinal hemorrhage, disseminated <br/ > intravascular coagulation or any other condition that in the PIâ??s <br/ > opinion makes the subject unfit to participate <br/ > Respiratory failure, ARDS or need of immediate mechanical <br/ > ventilation upon presentation <br/ > History of acute exacerbation of comorbidity like heart failure, <br/ > diabetic ketoacidosis, myocardial infection, major cardiac rhythm <br/ > disorder or any other condition that in the PIâ??s opinion makes the <br/ > subject unfit to participate <br/ > History of or current hepatic failure or severely compromised liver <br/ > function, or renal failure or having chronic kidney disease or acute <br/ > renal failure <br/ > History of or currently receiving treatment for an endocrine disorder <br/ > like hypothyroidism, hyperthyroidism that is likely to affect the basal <br/ > heart rate. <br/ > HIV, HBsAg, HCV positive <br/ > Any condition causing immunodeficiency <br/ > Systemic connective tissue disease or any autoimmune disease that <br/ > is likely to affect HS-CRP levels <br/ > History of epilepsy/epileptic fit/convulsions in last 6 months or <br/ > currently on treatment for it <br/ > History of or currently having malignancy and being treated for <br/ > it.exception histologically confirmed and cured carcinoma in situ <br/ > Hypersensitivity reaction to Study drug/active control <br/ > Any psychiatric issue for which the subject is currently undergoing <br/ > treatment <br/ > Any history of drug/alcohol dependence within 30 days of screening <br/ > or current drug/alcohol dependence <br/ > Inability to understand the requirements of the Research Protocol <br/ > and follow the research procedures. <br/ > Pregnant or lactating <br/ > Not willing to use adequate contraception during stu

Less than 40 years and older than 80 years <br/ > With severe COVID-19 symptomsrequiring immediate hospitalization <br/ > (Severe COVID-19: pneumonia with respiratory rate >30 <br/ > breaths/min, severe respiratory distress, SpO2 2 days ago <br/ > usingoropharyngeal/nasal swab RT-PCR for Sars-Co-V2 <br/ > History of cardiopulmonary resuscitation <br/ > Patient with a known history of DVT, PE, stroke, atrial <br/ > fibrillation,mechanical heart valve, recent stent placement or any <br/ > other cardiovascular event or any other condition for which the <br/ > patient is takingsystemic anticoagulation/antiplatelet therapy (LMWH, <br/ > coumadin, clopidogrel and/or other similar classes of therapy)prior to <br/ > study enrollment. <br/ > Patients on corticosteroids <br/ > Subjects having history of organ failure or conditions requiring ICU <br/ > monitoring and treatment, such as severe liver disease, severe renal <br/ > dysfunction, upper gastrointestinal hemorrhage, disseminated <br/ > intravascular coagulation or any other condition that in the PIâ??s <br/ > opinion makes the subject unfit to participate <br/ > Respiratory failure, ARDS or need of immediate mechanical <br/ > ventilation upon presentation <br/ > History of acute exacerbation of comorbidity like heart failure, <br/ > diabetic ketoacidosis, myocardial infection, major cardiac rhythm <br/ > disorder or any other condition that in the PIâ??s opinion makes the <br/ > subject unfit to participate <br/ > History of or current hepatic failure or severely compromised liver <br/ > function, or renal failure or having chronic kidney disease or acute <br/ > renal failure <br/ > History of or currently receiving treatment for an endocrine disorder <br/ > like hypothyroidism, hyperthyroidism that is likely to affect the basal <br/ > heart rate. <br/ > HIV, HBsAg, HCV positive <br/ > Any condition causing immunodeficiency <br/ > Systemic connective tissue disease or any autoimmune disease that <br/ > is likely to affect HS-CRP levels <br/ > History of epilepsy/epileptic fit/convulsions in last 6 months or <br/ > currently on treatment for it <br/ > History of or currently having malignancy and being treated for <br/ > it.exception histologically confirmed and cured carcinoma in situ <br/ > Hypersensitivity reaction to Study drug/active control <br/ > Any psychiatric issue for which the subject is currently undergoing <br/ > treatment <br/ > Any history of drug/alcohol dependence within 30 days of screening <br/ > or current drug/alcohol dependence <br/ > Inability to understand the requirements of the Research Protocol <br/ > and follow the research procedures. <br/ > Pregnant or lactating <br/ > Not willing to use adequate contraception during stu

Less than 40 years and older than 80 years <br/ >With severe COVID-19 symptomsrequiring immediate hospitalization <br/ >(Severe COVID-19: pneumonia with respiratory rate >30 <br/ >breaths/min, severe respiratory distress, SpO2 2 days ago <br/ >usingoropharyngeal/nasal swab RT-PCR for Sars-Co-V2 <br/ >History of cardiopulmonary resuscitation <br/ >Patient with a known history of DVT, PE, stroke, atrial <br/ >fibrillation,mechanical heart valve, recent stent placement or any <br/ >other cardiovascular event or any other condition for which the <br/ >patient is takingsystemic anticoagulation/antiplatelet therapy (LMWH, <br/ >coumadin, clopidogrel and/or other similar classes of therapy)prior to <br/ >study enrollment. <br/ >Patients on corticosteroids <br/ >Subjects having history of organ failure or conditions requiring ICU <br/ >monitoring and treatment, such as severe liver disease, severe renal <br/ >dysfunction, upper gastrointestinal hemorrhage, disseminated <br/ >intravascular coagulation or any other condition that in the PIâ??s <br/ >opinion makes the subject unfit to participate <br/ >Respiratory failure, ARDS or need of immediate mechanical <br/ >ventilation upon presentation <br/ >History of acute exacerbation of comorbidity like heart failure, <br/ >diabetic ketoacidosis, myocardial infection, major cardiac rhythm <br/ >disorder or any other condition that in the PIâ??s opinion makes the <br/ >subject unfit to participate <br/ >History of or current hepatic failure or severely compromised liver <br/ >function, or renal failure or having chronic kidney disease or acute <br/ >renal failure <br/ >History of or currently receiving treatment for an endocrine disorder <br/ >like hypothyroidism, hyperthyroidism that is likely to affect the basal <br/ >heart rate. <br/ >HIV, HBsAg, HCV positive <br/ >Any condition causing immunodeficiency <br/ >Systemic connective tissue disease or any autoimmune disease that <br/ >is likely to affect HS-CRP levels <br/ >History of epilepsy/epileptic fit/convulsions in last 6 months or <br/ >currently on treatment for it <br/ >History of or currently having malignancy and being treated for <br/ >it.exception histologically confirmed and cured carcinoma in situ <br/ >Hypersensitivity reaction to Study drug/active control <br/ >Any psychiatric issue for which the subject is currently undergoing <br/ >treatment <br/ >Any history of drug/alcohol dependence within 30 days of screening <br/ >or current drug/alcohol dependence <br/ >Inability to understand the requirements of the Research Protocol <br/ >and follow the research procedures. <br/ >Pregnant or lactating <br/ >Not willing to use adequate contraception during study duration <br/ >Participation in any other clinical study less than 3 months before the <br/ >start of the study. <br/ >

Less than 40 years and older than 80 years <br/ >With severe COVID-19 symptomsrequiring immediate hospitalization <br/ >(Severe COVID-19: pneumonia with respiratory rate >30 <br/ >breaths/min, severe respiratory distress, SpO2 2 days ago <br/ >usingoropharyngeal/nasal swab RT-PCR for Sars-Co-V2 <br/ >History of cardiopulmonary resuscitation <br/ >Patient with a known history of DVT, PE, stroke, atrial <br/ >fibrillation,mechanical heart valve, recent stent placement or any <br/ >other cardiovascular event or any other condition for which the <br/ >patient is takingsystemic anticoagulation/antiplatelet therapy (LMWH, <br/ >coumadin, clopidogrel and/or other similar classes of therapy)prior to <br/ >study enrollment. <br/ >Patients on corticosteroids <br/ >Subjects having history of organ failure or conditions requiring ICU <br/ >monitoring and treatment, such as severe liver disease, severe renal <br/ >dysfunction, upper gastrointestinal hemorrhage, disseminated <br/ >intravascular coagulation or any other condition that in the PIâ??s <br/ >opinion makes the subject unfit to participate <br/ >Respiratory failure, ARDS or need of immediate mechanical <br/ >ventilation upon presentation <br/ >History of acute exacerbation of comorbidity like heart failure, <br/ >diabetic ketoacidosis, myocardial infection, major cardiac rhythm <br/ >disorder or any other condition that in the PIâ??s opinion makes the <br/ >subject unfit to participate <br/ >History of or current hepatic failure or severely compromised liver <br/ >function, or renal failure or having chronic kidney disease or acute <br/ >renal failure <br/ >History of or currently receiving treatment for an endocrine disorder <br/ >like hypothyroidism, hyperthyroidism that is likely to affect the basal <br/ >heart rate. <br/ >HIV, HBsAg, HCV positive <br/ >Any condition causing immunodeficiency <br/ >Systemic connective tissue disease or any autoimmune disease that <br/ >is likely to affect HS-CRP levels <br/ >History of epilepsy/epileptic fit/convulsions in last 6 months or <br/ >currently on treatment for it <br/ >History of or currently having malignancy and being treated for <br/ >it.exception histologically confirmed and cured carcinoma in situ <br/ >Hypersensitivity reaction to Study drug/active control <br/ >Any psychiatric issue for which the subject is currently undergoing <br/ >treatment <br/ >Any history of drug/alcohol dependence within 30 days of screening <br/ >or current drug/alcohol dependence <br/ >Inability to understand the requirements of the Research Protocol <br/ >and follow the research procedures. <br/ >Pregnant or lactating <br/ >Not willing to use adequate contraception during study duration <br/ >Participation in any other clinical study less than 3 months before the <br/ >start of the study. <br/ >