Inclusion criteria Age 18 and older Health care worker in the private or public service The President and Deputy President of South africa (*The President and Deputy President of South Africa have been included in the protocol to address the issue of vaccine hesitancy.) Willingness and ability to comply vaccination plan and other study procedures. Capable of giving electronic or personal signed informed consent as described in Appendix 5, which includes compliance with the requirements in this protocol. Inclusion criteria for the sub-cohort Age 18 and older Health care worker in the private or public service Willingness and ability to comply with all scheduled visits, vaccination plan, laboratory tests, and other study procedures, with follow-up at an ENSEMBLE site. Capable of giving electronic or personal signed informed consent as described in Appendix 5, which includes compliance with the requirements in this protocol.

Inclusion criteria Age 18 and older Health care worker in the private or public service The President and Deputy President of South africa (*The President and Deputy President of South Africa have been included in the protocol to address the issue of vaccine hesitancy.) Willingness and ability to comply vaccination plan and other study procedures. Capable of giving electronic or personal signed informed consent as described in Appendix 5, which includes compliance with the requirements in this protocol. Inclusion criteria for the sub-cohort Age 18 and older Health care worker in the private or public service Willingness and ability to comply with all scheduled visits, vaccination plan, laboratory tests, and other study procedures, with follow-up at an ENSEMBLE site. Capable of giving electronic or personal signed informed consent as described in Appendix 5, which includes compliance with the requirements in this protocol.

Inclusion criteria Age 18 and older Health care worker in the private or public service Willingness and ability to comply with all scheduled visits, vaccination plan, laboratory tests, and other study procedures. Capable of giving electronic or personal signed informed consent as described in Appendix 5, which includes compliance with the requirements in this protocol.

Inclusion criteria Age 18 and older Health care worker in the private or public service Willingness and ability to comply with all scheduled visits, vaccination plan, laboratory tests, and other study procedures. Capable of giving electronic or personal signed informed consent as described in Appendix 5, which includes compliance with the requirements in this protocol.