INCLUSION CRITERIA: Firstly, participants must be in-patient adults 18 years of age and above. Secondly, having PCR-confirmed COVID-19 classified as mild, moderate or severe disease as per the FDA and admitted to the hospital for inpatient treatment as per the standard of care, with mild being a positive testing by standard RT-PCR assay or equivalent test and symptoms of mild illness with COVID-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea. No clinical signs indicative of Moderate, Severe, or Critical Severity. Moderate defined as positive testing by standard RT-PCR assay or equivalent testing and symptoms of moderate illness which could include any symptom of mild illness or shortness of breath with exertion. Clinical signs suggestive of moderate illness with COVID-19 include respiratory rate = 20 breaths per minute, saturation of oxygen (SpO2) &gt, 93% on room air at sea level, heart rate = 90 beats per minute without clinical signs indicative of Severe or Critical Illness Severity. Severe symptoms could include any symptom of moderate illness or shortness of breath at rest, or respiratory distress. Clinical signs indicative of severe systemic illness with COVID-19 include respiratory rate = 30 per minute, heart rate = 125 per minute, SpO2 = 93% on room air at sea level or PaO2/FiO2 &lt, 300. No criteria for Critical Severity.

INCLUSION CRITERIA: Firstly, participants must be in-patient adults 18 years of age and above. Secondly, having PCR-confirmed COVID-19 classified as mild, moderate or severe disease as per the FDA and admitted to the hospital for inpatient treatment as per the standard of care, with mild being a positive testing by standard RT-PCR assay or equivalent test and symptoms of mild illness with COVID-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea. No clinical signs indicative of Moderate, Severe, or Critical Severity. Moderate defined as positive testing by standard RT-PCR assay or equivalent testing and symptoms of moderate illness which could include any symptom of mild illness or shortness of breath with exertion. Clinical signs suggestive of moderate illness with COVID-19 include respiratory rate = 20 breaths per minute, saturation of oxygen (SpO2) &gt, 93% on room air at sea level, heart rate = 90 beats per minute without clinical signs indicative of Severe or Critical Illness Severity. Severe symptoms could include any symptom of moderate illness or shortness of breath at rest, or respiratory distress. Clinical signs indicative of severe systemic illness with COVID-19 include respiratory rate = 30 per minute, heart rate = 125 per minute, SpO2 = 93% on room air at sea level or PaO2/FiO2 &lt, 300. No criteria for Critical Severity.