EXCLUSION CRITERIA: Patients unable to tolerate oral medications. Patients who are already on beta-blockers, statins or Nicorandil, PDE5 inhibitors, Riociguat.. In addition to those with shock as defined by SBP&lt,90 for more than 30 minutes not responding to IV fluids with evidence of end organ damage. Patients with severe bradycardia (&lt,50 bpm) and heart block greater than first-degree (except in patients with a functioning artificial pacemaker) should be definitely excluded, along with those who suffer from decompensated heart failure and sick sinus syndrome (unless a permanent pacemaker is in place). Severe hepatic impairment (Child-Pugh class C) or active liver disease are absolute reasons not to be included especially those with unexplained persistent elevations of serum transaminases. Pregnancy or breastfeeding and hypersensitivity to any of the medications are to be excluded as well. Myocarditis. Acute pulmonary edema. Hypovolemia. Patients enrolled in a different randomized study and/or COVID interventional study.

EXCLUSION CRITERIA: Patients unable to tolerate oral medications. Patients who are already on beta-blockers, statins or Nicorandil, PDE5 inhibitors, Riociguat.. In addition to those with shock as defined by SBP&lt,90 for more than 30 minutes not responding to IV fluids with evidence of end organ damage. Patients with severe bradycardia (&lt,50 bpm) and heart block greater than first-degree (except in patients with a functioning artificial pacemaker) should be definitely excluded, along with those who suffer from decompensated heart failure and sick sinus syndrome (unless a permanent pacemaker is in place). Severe hepatic impairment (Child-Pugh class C) or active liver disease are absolute reasons not to be included especially those with unexplained persistent elevations of serum transaminases. Pregnancy or breastfeeding and hypersensitivity to any of the medications are to be excluded as well. Myocarditis. Acute pulmonary edema. Hypovolemia. Patients enrolled in a different randomized study and/or COVID interventional study.