Subjects who meet any of the following criteria will be excluded from the study: <br/ > <br/ >1) Subjects who have a clinically significant active Oral Cavity disease. <br/ >2) Subjects who have a history of recent Oral ongoing treatment. <br/ >3) Subjects who have a condition or are taking medication(s) which, in the judgment of the Investigator or Designate, makes the subject ineligible or places the subject at undue risk. <br/ >4) Subjects who have received treatment (chemotherapy, radiation, immune suppressant medications) for any type of cancer within the last 6 months. <br/ >5) Subjects who are currently participating in any another study related to Oral applications. <br/ >6) Subjects who are currently participating in any clinical study, which in the judgment of the Investigator, could potentially affect responses in either study or have participated in a clinical study in the recent past up to three months. <br/ >7) Subjects who have a known sensitivity or allergy relating to the substance(s) being evaluated. <br/ >8) Subjects who are Pregnant, lactating or have the intention to become pregnant during trial period as determined by questioning the subject. <br/ >9) Subjects with any pharyngeal, or laryngeal finding which precludes bronchoscopy.

Subjects who meet any of the following criteria will be excluded from the study: <br/ > <br/ >1) Subjects who have a clinically significant active Oral Cavity disease. <br/ >2) Subjects who have a history of recent Oral ongoing treatment. <br/ >3) Subjects who have a condition or are taking medication(s) which, in the judgment of the Investigator or Designate, makes the subject ineligible or places the subject at undue risk. <br/ >4) Subjects who have received treatment (chemotherapy, radiation, immune suppressant medications) for any type of cancer within the last 6 months. <br/ >5) Subjects who are currently participating in any another study related to Oral applications. <br/ >6) Subjects who are currently participating in any clinical study, which in the judgment of the Investigator, could potentially affect responses in either study or have participated in a clinical study in the recent past up to three months. <br/ >7) Subjects who have a known sensitivity or allergy relating to the substance(s) being evaluated. <br/ >8) Subjects who are Pregnant, lactating or have the intention to become pregnant during trial period as determined by questioning the subject. <br/ >9) Subjects with any pharyngeal, or laryngeal finding which precludes bronchoscopy.

N/A

N/A

Subjects who meet any of the following criteria will be excluded from the study: <br/ > <br/ >1) Subjects who have a clinically significant active Oral Cavity disease. <br/ >2) Subjects who have a history of recent Oral ongoing treatment. <br/ >3) Subjects who have a condition or are taking medication(s) which, in the judgment of the Investigator or Designate, makes the subject ineligible or places the subject at undue risk. <br/ >4) Subjects who have received treatment (chemotherapy, radiation, immune suppressant medications) for any type of cancer within the last 6 months. <br/ >5) Subjects who are currently participating in any another study related to Oral applications. <br/ >6) Subjects who are currently participating in any clinical study, which in the judgment of the Investigator, could potentially affect responses in either study or have participated in a clinical study in the recent past up to three months. <br/ >7) Subjects who have a known sensitivity or allergy relating to the substance(s) being evaluated. <br/ >8) Subjects who are Pregnant, lactating or have the intention to become pregnant during trial period as determined by questioning the subject. <br/ >9) Subjects with any pharyngeal, or laryngeal finding which precludes bronchoscopy.

Subjects who meet any of the following criteria will be excluded from the study: <br/ > <br/ >1) Subjects who have a clinically significant active Oral Cavity disease. <br/ >2) Subjects who have a history of recent Oral ongoing treatment. <br/ >3) Subjects who have a condition or are taking medication(s) which, in the judgment of the Investigator or Designate, makes the subject ineligible or places the subject at undue risk. <br/ >4) Subjects who have received treatment (chemotherapy, radiation, immune suppressant medications) for any type of cancer within the last 6 months. <br/ >5) Subjects who are currently participating in any another study related to Oral applications. <br/ >6) Subjects who are currently participating in any clinical study, which in the judgment of the Investigator, could potentially affect responses in either study or have participated in a clinical study in the recent past up to three months. <br/ >7) Subjects who have a known sensitivity or allergy relating to the substance(s) being evaluated. <br/ >8) Subjects who are Pregnant, lactating or have the intention to become pregnant during trial period as determined by questioning the subject. <br/ >9) Subjects with any pharyngeal, or laryngeal finding which precludes bronchoscopy.