Current exclusion criteria as of 13/05/2021: 1. Patients who require invasive or non-invasive (including CPAP and high flow nasal cannula). ventilation at the time of inclusion 2. AST/ALT values >5 fold the upper normal limit 3. Impairment of renal function( creatinine clearance<30ml/min/m²) 4. Absolute neutrophil count below 500 cells/mm³ 5. Absolute platelet count below 50,000 cells/mm³ 6. Documented sepsis or high clinical suspicion of superimposed severe bacterial or fungal infection 7. Concomitant acute medical emergencies, such as AMI, acute pericarditis, PE, stroke, acute Surgical and orthopaedic emergencies like acute abdomen and fractured neck of femur etc. 8. Comobidities or concomitant medications likely to be incompatible for cotrimoxazole use pregnancy or lactation 9. History of cotrimoxazole hypersensitivity 10. Patients participating in another clinical trial for SARS-CoV-2 infection _____ Previous exclusion criteria: 1. Require invasive or non-invasive (including CPAP and high flow nasal cannula) ventilation at the time of inclusion 2. Aspartate transaminase (AST)/alanine transaminase (ALT) ratio >5 times the ULN 3. Documented impairment of renal function 4. Absolute neutrophil count <500 cells/mm³ 5. Absolute platelet count <50,000 cells/mm³ 6. Documented sepsis or high suspicion of superimposed severe bacterial or fungal infection 7. Comorbidities or concomitant medications likely to be incompatible for cotrimoxazole use 8. Pregnancy or lactation 9. History of cotrimoxazole hypersensitivity 10. Participating in another clinical trial for SARS-CoV-2 infection

Current exclusion criteria as of 13/05/2021: 1. Patients who require invasive or non-invasive (including CPAP and high flow nasal cannula). ventilation at the time of inclusion 2. AST/ALT values >5 fold the upper normal limit 3. Impairment of renal function( creatinine clearance<30ml/min/m²) 4. Absolute neutrophil count below 500 cells/mm³ 5. Absolute platelet count below 50,000 cells/mm³ 6. Documented sepsis or high clinical suspicion of superimposed severe bacterial or fungal infection 7. Concomitant acute medical emergencies, such as AMI, acute pericarditis, PE, stroke, acute Surgical and orthopaedic emergencies like acute abdomen and fractured neck of femur etc. 8. Comobidities or concomitant medications likely to be incompatible for cotrimoxazole use pregnancy or lactation 9. History of cotrimoxazole hypersensitivity 10. Patients participating in another clinical trial for SARS-CoV-2 infection _____ Previous exclusion criteria: 1. Require invasive or non-invasive (including CPAP and high flow nasal cannula) ventilation at the time of inclusion 2. Aspartate transaminase (AST)/alanine transaminase (ALT) ratio >5 times the ULN 3. Documented impairment of renal function 4. Absolute neutrophil count <500 cells/mm³ 5. Absolute platelet count <50,000 cells/mm³ 6. Documented sepsis or high suspicion of superimposed severe bacterial or fungal infection 7. Comorbidities or concomitant medications likely to be incompatible for cotrimoxazole use 8. Pregnancy or lactation 9. History of cotrimoxazole hypersensitivity 10. Participating in another clinical trial for SARS-CoV-2 infection

1. Require invasive or non-invasive (including CPAP and high flow nasal cannula) ventilation at the time of inclusion 2. Aspartate transaminase (AST)/alanine transaminase (ALT) ratio >5 times the ULN 3. Documented impairment of renal function 4. Absolute neutrophil count <500 cells/mm³ 5. Absolute platelet count <50,000 cells/mm³ 6. Documented sepsis or high suspicion of superimposed severe bacterial or fungal infection 7. Comorbidities or concomitant medications likely to be incompatible for cotrimoxazole use 8. Pregnancy or lactation 9. History of cotrimoxazole hypersensitivity 10. Participating in another clinical trial for SARS-CoV-2 infection

1. Require invasive or non-invasive (including CPAP and high flow nasal cannula) ventilation at the time of inclusion 2. Aspartate transaminase (AST)/alanine transaminase (ALT) ratio >5 times the ULN 3. Documented impairment of renal function 4. Absolute neutrophil count <500 cells/mm³ 5. Absolute platelet count <50,000 cells/mm³ 6. Documented sepsis or high suspicion of superimposed severe bacterial or fungal infection 7. Comorbidities or concomitant medications likely to be incompatible for cotrimoxazole use 8. Pregnancy or lactation 9. History of cotrimoxazole hypersensitivity 10. Participating in another clinical trial for SARS-CoV-2 infection