1. History of laboratory confirmed COVID-19 (A positive result on a validated test for SARS-CoV-2 or seropositivity for SARS-CoV-2 before enrolment) 2. Chronic respiratory diseases, including mild asthma (resolved childhood asthma is allowed) 3. Prior receipt of MenB vaccine 4. Prior receipt of any vaccines (licensed or investigational) =30 days before enrolment 5. Planned receipt of any vaccine other than the study intervention within 30 days before and after each study vaccination 6. Prior receipt of an investigational or licensed vaccine likely to impact on interpretation of the trial data (e.g. Adenovirus vectored vaccines, any coronavirus vaccines) 7. Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate 8. Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV infection, asplenia, recurrent severe infections and use of immunosuppressant medication within the past 6 months, except topical steroids or short-term oral steroids (course lasting <14 days) 9. Any autoimmune conditions, 10. History of allergic disease or reactions likely to be exacerbated by any component of the ChAdOx1 nCoV-19 or MenB vaccines 11. Previous diagnosis of Kawasaki disease 12. Any history of angioedema 13. Any history of anaphylaxis 14. Pregnancy, lactation or willingness/intention to become pregnant during the study 15. Any history of cancer 16. Bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following IM injections or venepuncture 17. Any other serious chronic illness requiring hospital specialist supervision 18. Congenital cardiovascular conditions 19. Any other significant disease, disorder or finding which may significantly increase the risk to the participant because of participation in the study, affect the ability of the participant to participate in the study or impair interpretation of the study data 20. Child of a staff member of the Oxford Vaccine Group

1. History of laboratory confirmed COVID-19 (A positive result on a validated test for SARS-CoV-2 or seropositivity for SARS-CoV-2 before enrolment) 2. Chronic respiratory diseases, including mild asthma (resolved childhood asthma is allowed) 3. Prior receipt of MenB vaccine 4. Prior receipt of any vaccines (licensed or investigational) =30 days before enrolment 5. Planned receipt of any vaccine other than the study intervention within 30 days before and after each study vaccination 6. Prior receipt of an investigational or licensed vaccine likely to impact on interpretation of the trial data (e.g. Adenovirus vectored vaccines, any coronavirus vaccines) 7. Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate 8. Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV infection, asplenia, recurrent severe infections and use of immunosuppressant medication within the past 6 months, except topical steroids or short-term oral steroids (course lasting <14 days) 9. Any autoimmune conditions, 10. History of allergic disease or reactions likely to be exacerbated by any component of the ChAdOx1 nCoV-19 or MenB vaccines 11. Previous diagnosis of Kawasaki disease 12. Any history of angioedema 13. Any history of anaphylaxis 14. Pregnancy, lactation or willingness/intention to become pregnant during the study 15. Any history of cancer 16. Bleeding disorder (e.g. factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following IM injections or venepuncture 17. Any other serious chronic illness requiring hospital specialist supervision 18. Congenital cardiovascular conditions 19. Any other significant disease, disorder or finding which may significantly increase the risk to the participant because of participation in the study, affect the ability of the participant to participate in the study or impair interpretation of the study data 20. Child of a staff member of the Oxford Vaccine Group