Outcome name:Blinded adjudication by the investigators based on systematic data collection regarding the clinical course of study participants.Measure:Primary endpoint: global rank score that ranks patient outcomes according to 5 factors: (1) time to death (ranked from lower to higher; up to 30 days post-randomization); (2) the number of days in mechanical ventilatory support (invasive or non-invasive) or extracorporeal membrane oxygenation (up to discharge; evaluated up to 30 days post-randomization; ranked from highest to lowest); (3) The area under the curve in the ratio inspired oxygen fraction/oxygen saturation percentage (FiO2/SpO2; up to discharge; evaluated up to 30 days post-randomization; ranked from highest to lowest); (4) For participants enrolled as outpatients who are subsequently hospitalized; the number of days out of the hospital during the 30-day period following randomization (ranked from lowest to highest.Timepoints:30 days.

Outcome name:Blinded adjudication by the investigators based on systematic data collection regarding the clinical course of study participants.Measure:Primary endpoint: global rank score that ranks patient outcomes according to 5 factors: (1) time to death (ranked from lower to higher; up to 30 days post-randomization); (2) the number of days in mechanical ventilatory support (invasive or non-invasive) or extracorporeal membrane oxygenation (up to discharge; evaluated up to 30 days post-randomization; ranked from highest to lowest); (3) The area under the curve in the ratio inspired oxygen fraction/oxygen saturation percentage (FiO2/SpO2; up to discharge; evaluated up to 30 days post-randomization; ranked from highest to lowest); (4) For participants enrolled as outpatients who are subsequently hospitalized; the number of days out of the hospital during the 30-day period following randomization (ranked from lowest to highest.Timepoints:30 days.