1. Patients presenting severe multisystemic symptoms compatible with advanced Covid-19 and intercurrent acute or severe chronic diseases (i.e. active cancer). <br/ >2. Presence of acute hypoxic respiratory failure <br/ >3. Requires Intensive care unit (ICU) care for management of ongoing clinical status <br/ >4. Severe infection, defined as need for invasive or non-invasive ventilator support <br/ >5. Inability to intake or tolerate oral medication <br/ >6. Category 6 or 5 based on modified 7-category ordinal scale of clinical status <br/ >7. Clinical prognostic non-survival, palliative care, and have no response to supportive treatment within three hours of admission <br/ >8. Pregnant or lactating subjects <br/ >9. With any secondary complication such as diabetes, cancer, HIV or hypertension.

1. Patients presenting severe multisystemic symptoms compatible with advanced Covid-19 and intercurrent acute or severe chronic diseases (i.e. active cancer). <br/ >2. Presence of acute hypoxic respiratory failure <br/ >3. Requires Intensive care unit (ICU) care for management of ongoing clinical status <br/ >4. Severe infection, defined as need for invasive or non-invasive ventilator support <br/ >5. Inability to intake or tolerate oral medication <br/ >6. Category 6 or 5 based on modified 7-category ordinal scale of clinical status <br/ >7. Clinical prognostic non-survival, palliative care, and have no response to supportive treatment within three hours of admission <br/ >8. Pregnant or lactating subjects <br/ >9. With any secondary complication such as diabetes, cancer, HIV or hypertension.

N/A

N/A

1. Patients presenting severe multisystemic symptoms compatible with advanced Covid-19 and intercurrent acute or severe chronic diseases (i.e. active cancer). <br/ >2. Presence of acute hypoxic respiratory failure <br/ >3. Requires Intensive care unit (ICU) care for management of ongoing clinical status <br/ >4. Severe infection, defined as need for invasive or non-invasive ventilator support <br/ >5. Inability to intake or tolerate oral medication <br/ >6. Category 6 or 5 based on modified 7-category ordinal scale of clinical status <br/ >7. Clinical prognostic non-survival, palliative care, and have no response to supportive treatment within three hours of admission <br/ >8. Pregnant or lactating subjects <br/ >9. With any secondary complication such as diabetes, cancer, HIV or hypertension.

1. Patients presenting severe multisystemic symptoms compatible with advanced Covid-19 and intercurrent acute or severe chronic diseases (i.e. active cancer). <br/ >2. Presence of acute hypoxic respiratory failure <br/ >3. Requires Intensive care unit (ICU) care for management of ongoing clinical status <br/ >4. Severe infection, defined as need for invasive or non-invasive ventilator support <br/ >5. Inability to intake or tolerate oral medication <br/ >6. Category 6 or 5 based on modified 7-category ordinal scale of clinical status <br/ >7. Clinical prognostic non-survival, palliative care, and have no response to supportive treatment within three hours of admission <br/ >8. Pregnant or lactating subjects <br/ >9. With any secondary complication such as diabetes, cancer, HIV or hypertension.