1.Time to Clinical Improvement (TTCI; censored at Day 28; time frame: up to 28 days) <br/ >TTCI is defined as the time (in days) from initiation of study treatment (active or placebo) until a decline of two categories from status at randomisation on a 7 category ordinal scale of clinical status which ranges <br/ >from 1 (discharged) to 7 (death) as per WHO R&D Blueprint expert group. The 7-category ordinal scale <br/ >Timepoint: Day 1- Day 28

1.Time to Clinical Improvement (TTCI; censored at Day 28; time frame: up to 28 days) <br/ >TTCI is defined as the time (in days) from initiation of study treatment (active or placebo) until a decline of two categories from status at randomisation on a 7 category ordinal scale of clinical status which ranges <br/ >from 1 (discharged) to 7 (death) as per WHO R&D Blueprint expert group. The 7-category ordinal scale <br/ >Timepoint: Day 1- Day 28

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1.Time to Clinical Improvement (TTCI; censored at Day 28; time frame: up to 28 days) <br/ >TTCI is defined as the time (in days) from initiation of study treatment (active or placebo) until a decline of two categories from status at randomisation on a 7 category ordinal scale of clinical status which ranges <br/ >from 1 (discharged) to 7 (death) as per WHO R&D Blueprint expert group. The 7-category ordinal scale <br/ >Timepoint: Day 1- Day 28

1.Time to Clinical Improvement (TTCI; censored at Day 28; time frame: up to 28 days) <br/ >TTCI is defined as the time (in days) from initiation of study treatment (active or placebo) until a decline of two categories from status at randomisation on a 7 category ordinal scale of clinical status which ranges <br/ >from 1 (discharged) to 7 (death) as per WHO R&D Blueprint expert group. The 7-category ordinal scale <br/ >Timepoint: Day 1- Day 28