1. Patients 18 years or older <br/ >2. Diagnosis of SARS-CoV-2 infection by RT-PCR <br/ >3. Pulmonary infiltrates on CXR/ CECT Chest <br/ >4. On COVID specific steroid therapy with IV methyl prednisolone 1 mg/kg/day or dexamethasone 6 mg per day <br/ >5. Severe respiratory failure with PaO2 / FiO2 less than 150 mmHg and IL-6 > 50 pg/mL with CRP > 50 mg/L <br/ >6. Signature of informed consent by the patient, family member or legal representative <br/ >

1. Patients 18 years or older <br/ >2. Diagnosis of SARS-CoV-2 infection by RT-PCR <br/ >3. Pulmonary infiltrates on CXR/ CECT Chest <br/ >4. On COVID specific steroid therapy with IV methyl prednisolone 1 mg/kg/day or dexamethasone 6 mg per day <br/ >5. Severe respiratory failure with PaO2 / FiO2 less than 150 mmHg and IL-6 > 50 pg/mL with CRP > 50 mg/L <br/ >6. Signature of informed consent by the patient, family member or legal representative <br/ >

1. Patients 18 years or older <br/ >2. Diagnosis of SARS-CoV-2 infection by RT-PCR <br/ >3. Pulmonary infiltrates on CXR/ CECT Chest <br/ >4. On COVID specific steroid therapy with IV methyl prednisolone 1 mg/kg/day or dexamethasone 6 mg per day <br/ >5. Severe respiratory failure with PaO2 / FiO2 less than 150 mmHg and IL-6 > 50 pg/mL with CRP > 50 mg/L <br/ >6. Signature of informed consent by the patient, family member or legal representative <br/ >

1. Patients 18 years or older <br/ >2. Diagnosis of SARS-CoV-2 infection by RT-PCR <br/ >3. Pulmonary infiltrates on CXR/ CECT Chest <br/ >4. On COVID specific steroid therapy with IV methyl prednisolone 1 mg/kg/day or dexamethasone 6 mg per day <br/ >5. Severe respiratory failure with PaO2 / FiO2 less than 150 mmHg and IL-6 > 50 pg/mL with CRP > 50 mg/L <br/ >6. Signature of informed consent by the patient, family member or legal representative <br/ >