1.Less than 24 hrs of initiation of steroid therapy <br/ >2. Liver injury or failure (AST/ALT � 5x Upper limit of normal) <br/ >3. Leukocytes < 2 � 103/μl <br/ >4. Thrombocytes < 50 � 103/μl <br/ >5. Severe bacterial infection (Procalcitonin > 3ng/ml) <br/ >6. Acute or chronic diverticulitis <br/ >7. Immunosuppressive therapy (e.g. mycophenolate, azathioprine, methotrexate and biologicals) <br/ >8. Known active or chronic tuberculosis <br/ >9. Known active or chronic viral hepatitis <br/ >10. Known allergic reactions to tocilizumab or its ingredients <br/ >

1.Less than 24 hrs of initiation of steroid therapy <br/ >2. Liver injury or failure (AST/ALT � 5x Upper limit of normal) <br/ >3. Leukocytes < 2 � 103/μl <br/ >4. Thrombocytes < 50 � 103/μl <br/ >5. Severe bacterial infection (Procalcitonin > 3ng/ml) <br/ >6. Acute or chronic diverticulitis <br/ >7. Immunosuppressive therapy (e.g. mycophenolate, azathioprine, methotrexate and biologicals) <br/ >8. Known active or chronic tuberculosis <br/ >9. Known active or chronic viral hepatitis <br/ >10. Known allergic reactions to tocilizumab or its ingredients <br/ >

N/A

N/A

1.Less than 24 hrs of initiation of steroid therapy <br/ >2. Liver injury or failure (AST/ALT � 5x Upper limit of normal) <br/ >3. Leukocytes < 2 � 103/μl <br/ >4. Thrombocytes < 50 � 103/μl <br/ >5. Severe bacterial infection (Procalcitonin > 3ng/ml) <br/ >6. Acute or chronic diverticulitis <br/ >7. Immunosuppressive therapy (e.g. mycophenolate, azathioprine, methotrexate and biologicals) <br/ >8. Known active or chronic tuberculosis <br/ >9. Known active or chronic viral hepatitis <br/ >10. Known allergic reactions to tocilizumab or its ingredients <br/ >

1.Less than 24 hrs of initiation of steroid therapy <br/ >2. Liver injury or failure (AST/ALT � 5x Upper limit of normal) <br/ >3. Leukocytes < 2 � 103/μl <br/ >4. Thrombocytes < 50 � 103/μl <br/ >5. Severe bacterial infection (Procalcitonin > 3ng/ml) <br/ >6. Acute or chronic diverticulitis <br/ >7. Immunosuppressive therapy (e.g. mycophenolate, azathioprine, methotrexate and biologicals) <br/ >8. Known active or chronic tuberculosis <br/ >9. Known active or chronic viral hepatitis <br/ >10. Known allergic reactions to tocilizumab or its ingredients <br/ >