Created at Source Raw Value Validated value
Nov. 26, 2021, 10:30 p.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: Early liberal oxygen therapy - PART I: Part I: Patients will be randomized to liberal oxygen supplementation where patient will be supplemented with oxygen with nasal prongs at a rate of 0.5L/min and assessed continually for vital signs and every 4 hours for symptoms. If not symptomatically improved; oxygen will be increased at a rate of 0.5L/min per 4 hours to a maximum of 2L/min. Patient will be monitored continuously for next 5 days and watched for clinical deterioration or symptomatic relief which will be marked as an event. If during study period; any patient has increasing symptoms with desaturation (94%) or develops new symptoms discomfort due to oxygen flow or tinnitus; blurring of vision; study will be stopped for that particular patient and marked as an event and will be offered usual care as per the discretion of the treating physician.Intervention2: Early liberal target -PART II: Part II: Patients will be randomized to liberal oxygen supplementation with a PaO2 target of 90-105 mmHg (approximately oxygen saturation of \u00e2?\u00a596%) versus usual target of 60-75 mmHg (approximately oxygen saturation of 90-94%) after enrollment and informed consent. Randomization will be done using random number generation using standard software. The resident doctor on duty will call the designated person (one of the PIs) for allocation over phone. Allocation will be concealed from the nursing staff/resident doctor and the patient prior to that time. This will be an open-labeled study. Baseline parameters related to demographic data; clinical features; laboratory investigations and previous comorbidities/treatment will be collected. Intervention: Patients in liberal oxygen supplementation group will be supplemented with nasal oxygen using prongs/cannula or face-mask", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 430, "treatment_name": "Early liberal oxygen therapy", "treatment_type": "Respiratory support", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]

Nov. 13, 2021, 5:33 p.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "N/A", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

Jan. 15, 2021, 12:45 a.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: Early liberal oxygen therapy - PART I: Part I: Patients will be randomized to liberal oxygen supplementation where patient will be supplemented with oxygen with nasal prongs at a rate of 0.5L/min and assessed continually for vital signs and every 4 hours for symptoms. If not symptomatically improved; oxygen will be increased at a rate of 0.5L/min per 4 hours to a maximum of 2L/min. Patient will be monitored continuously for next 5 days and watched for clinical deterioration or symptomatic relief which will be marked as an event. If during study period; any patient has increasing symptoms with desaturation (94%) or develops new symptoms discomfort due to oxygen flow or tinnitus; blurring of vision; study will be stopped for that particular patient and marked as an event and will be offered usual care as per the discretion of the treating physician.Intervention2: Early liberal target -PART II: Part II: Patients will be randomized to liberal oxygen supplementation with a PaO2 target of 90-105 mmHg (approximately oxygen saturation of \u00e2?\u00a596%) versus usual target of 60-75 mmHg (approximately oxygen saturation of 90-94%) after enrollment and informed consent. Randomization will be done using random number generation using standard software. The resident doctor on duty will call the designated person (one of the PIs) for allocation over phone. Allocation will be concealed from the nursing staff/resident doctor and the patient prior to that time. This will be an open-labeled study. Baseline parameters related to demographic data; clinical features; laboratory investigations and previous comorbidities/treatment will be collected. Intervention: Patients in liberal oxygen supplementation group will be supplemented with nasal oxygen using prongs/cannula or face-mask", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]