1. A healthy person aged 18-59 who can provide the legal identification of the subjects, both male and female, 2. The subjects who knew the content of informed consent and the vaccination situation voluntarily signed the informed consent, and had the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Subjects who can communicate well with researchers and understand and comply with the requirements of this study, four The subjects who had used effective contraceptive measures within 2 weeks before being enrolled in this study had negative pregnancy test (those with amenorrhea for at least 1 year or surgical sterilization with medical records could be exempted from pregnancy test), and voluntarily agreed to continue to use effective contraceptive measures within 12 months after full immunization, such as oral contraceptive, injection or embedded contraceptive, slow-release local contraceptive, hormone patch, intrauterine contraceptive IUD, sterilization, condom (male), diaphragm, cervical cap, etc, 5. Subjects with axillary temperature < 37.3 degrees C on the day of inoculation.

1. A healthy person aged 18-59 who can provide the legal identification of the subjects, both male and female, 2. The subjects who knew the content of informed consent and the vaccination situation voluntarily signed the informed consent, and had the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Subjects who can communicate well with researchers and understand and comply with the requirements of this study, four The subjects who had used effective contraceptive measures within 2 weeks before being enrolled in this study had negative pregnancy test (those with amenorrhea for at least 1 year or surgical sterilization with medical records could be exempted from pregnancy test), and voluntarily agreed to continue to use effective contraceptive measures within 12 months after full immunization, such as oral contraceptive, injection or embedded contraceptive, slow-release local contraceptive, hormone patch, intrauterine contraceptive IUD, sterilization, condom (male), diaphragm, cervical cap, etc, 5. Subjects with axillary temperature < 37.3 degrees C on the day of inoculation.

1. Healthy adults aged 18-59 years who can provide legal identity certificate of their own, both males and females are acceptable, 2. Subjects who understand the contents of the informed consent form and the background of the investigation vaccine, agree to sign the informed consent form voluntarily, and are able to use thermometer and scale, and may fill in the diary card and contact card as required, 3. Subjects who are able to have good communicate with investigator(s), understand and comply with the requirements of this study, 4. Having taken effective measures for contraception 2 weeks before enrollment, women with negative pregnancy test (which may be exempt for women in menstrual phase or with amenorrhea for at least 1 year or who have medical records of surgical sterilization) and who plan to conceive within 12 months from the screening period to completion of immunizations, 5. Axillary temperature<37.3 degree C on the day of vaccination.

1. Healthy adults aged 18-59 years who can provide legal identity certificate of their own, both males and females are acceptable, 2. Subjects who understand the contents of the informed consent form and the background of the investigation vaccine, agree to sign the informed consent form voluntarily, and are able to use thermometer and scale, and may fill in the diary card and contact card as required, 3. Subjects who are able to have good communicate with investigator(s), understand and comply with the requirements of this study, 4. Having taken effective measures for contraception 2 weeks before enrollment, women with negative pregnancy test (which may be exempt for women in menstrual phase or with amenorrhea for at least 1 year or who have medical records of surgical sterilization) and who plan to conceive within 12 months from the screening period to completion of immunizations, 5. Axillary temperature<37.3 degree C on the day of vaccination.