1. Positive serum IgM and IgG to the SARS-CoV-2, 2. History of HIV infection 3. Family history of seizure, epilepsy, brain or mental disease. 4. Participant that has an allergic history to any ingredient of vaccines, 5. oman who is pregnant, breast-feeding or positive in pregnancy test on day of enrollment, or is planning to be pregnant during the next 6 months, 6. Any acute fever disease or infections, 7. Have a medical history of SARS, 8. Have serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension and not well-controlled, 9. Major chronic illness, such as asthma, diabetes, or thyroid disease, and not well-controlled, 10. Hereditary angioneurotic edema or acquired angioneurotic edema, 11. Urticaria in last one year, 12. Asplenia or functional asplenia, 13. Platelet disorder or other bleeding disorder may cause injection contraindication, 14. Faint at the sight of blood or needles, 15. Prior administration of immunodepressant or corticosteroids, antianaphylaxis treatment, cytotoxic treatment in last 6 months, 16. Prior administration of blood products in last 4 months, 17. Prior administration of other research medicines in last 1 month, 18. Prior administration of attenuated vaccine in last 1 month, 19. Prior administration of subunit vaccine or inactivated vaccine in last 14 days, 20. Being treated for tuberculosis, 21. Any condition that in the opinion of the investigators may interfere with the evaluation of study objectives.

1. Positive serum IgM and IgG to the SARS-CoV-2, 2. History of HIV infection 3. Family history of seizure, epilepsy, brain or mental disease. 4. Participant that has an allergic history to any ingredient of vaccines, 5. oman who is pregnant, breast-feeding or positive in pregnancy test on day of enrollment, or is planning to be pregnant during the next 6 months, 6. Any acute fever disease or infections, 7. Have a medical history of SARS, 8. Have serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension and not well-controlled, 9. Major chronic illness, such as asthma, diabetes, or thyroid disease, and not well-controlled, 10. Hereditary angioneurotic edema or acquired angioneurotic edema, 11. Urticaria in last one year, 12. Asplenia or functional asplenia, 13. Platelet disorder or other bleeding disorder may cause injection contraindication, 14. Faint at the sight of blood or needles, 15. Prior administration of immunodepressant or corticosteroids, antianaphylaxis treatment, cytotoxic treatment in last 6 months, 16. Prior administration of blood products in last 4 months, 17. Prior administration of other research medicines in last 1 month, 18. Prior administration of attenuated vaccine in last 1 month, 19. Prior administration of subunit vaccine or inactivated vaccine in last 14 days, 20. Being treated for tuberculosis, 21. Any condition that in the opinion of the investigators may interfere with the evaluation of study objectives.