inclusion criteria: * informed consent as documented by signature * admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection * evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) * symptom onset within the previous 10 days or shortness of breath within the previous 5 days. symptoms include fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment). respiratory symptoms include cough, sore throat, hemoptysis, shortness of breath, runny nose, or chest pain. * expected to remain an inpatient over the next three calender days from time of enrolment * at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) \>50 years, 3) obesity (bmi\>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of \>35mg/l, 7) oxygen saturation at rest in ambient air of \<94%. cardiovascular disease includes a history of coronary artery disease, cerebrovascular disease, peripheral artery disease, rheumatic heart disease, congenital heart disease and of recent (\< 3 months) deep vein thrombosis or pulmonary embolism. chronic pulmonary disease includes a history of chronic obstructive pulmonary disease, asthma, occupational lung disease, interstitial lung disease or of pulmonary hypertension. chronic renal disease is defined as a history of an estimated glomerular filtration rate (according to the chronic kidney disease epidemiology collaboration equation) \< 60ml/min/1.73 m2 for at least three months.

inclusion criteria: * informed consent as documented by signature * admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection * evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) * symptom onset within the previous 10 days or shortness of breath within the previous 5 days. symptoms include fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment). respiratory symptoms include cough, sore throat, hemoptysis, shortness of breath, runny nose, or chest pain. * expected to remain an inpatient over the next three calender days from time of enrolment * at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) \>50 years, 3) obesity (bmi\>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of \>35mg/l, 7) oxygen saturation at rest in ambient air of \<94%. cardiovascular disease includes a history of coronary artery disease, cerebrovascular disease, peripheral artery disease, rheumatic heart disease, congenital heart disease and of recent (\< 3 months) deep vein thrombosis or pulmonary embolism. chronic pulmonary disease includes a history of chronic obstructive pulmonary disease, asthma, occupational lung disease, interstitial lung disease or of pulmonary hypertension. chronic renal disease is defined as a history of an estimated glomerular filtration rate (according to the chronic kidney disease epidemiology collaboration equation) \< 60ml/min/1.73 m2 for at least three months.

inclusion criteria: - informed consent as documented by signature - admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection - evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) - symptom onset within the previous 10 days or shortness of breath within the previous 5 days. symptoms include fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment). respiratory symptoms include cough, sore throat, hemoptysis, shortness of breath, runny nose, or chest pain. - expected to remain an inpatient over the next three calender days from time of enrolment - at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) >50 years, 3) obesity (bmi>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of >35mg/l, 7) oxygen saturation at rest in ambient air of <94%. cardiovascular disease includes a history of coronary artery disease, cerebrovascular disease, peripheral artery disease, rheumatic heart disease, congenital heart disease and of recent (< 3 months) deep vein thrombosis or pulmonary embolism. chronic pulmonary disease includes a history of chronic obstructive pulmonary disease, asthma, occupational lung disease, interstitial lung disease or of pulmonary hypertension. chronic renal disease is defined as a history of an estimated glomerular filtration rate (according to the chronic kidney disease epidemiology collaboration equation) < 60ml/min/1.73 m2 for at least three months.

inclusion criteria: - informed consent as documented by signature - admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection - evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) - symptom onset within the previous 10 days or shortness of breath within the previous 5 days. symptoms include fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment). respiratory symptoms include cough, sore throat, hemoptysis, shortness of breath, runny nose, or chest pain. - expected to remain an inpatient over the next three calender days from time of enrolment - at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) >50 years, 3) obesity (bmi>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of >35mg/l, 7) oxygen saturation at rest in ambient air of <94%. cardiovascular disease includes a history of coronary artery disease, cerebrovascular disease, peripheral artery disease, rheumatic heart disease, congenital heart disease and of recent (< 3 months) deep vein thrombosis or pulmonary embolism. chronic pulmonary disease includes a history of chronic obstructive pulmonary disease, asthma, occupational lung disease, interstitial lung disease or of pulmonary hypertension. chronic renal disease is defined as a history of an estimated glomerular filtration rate (according to the chronic kidney disease epidemiology collaboration equation) < 60ml/min/1.73 m2 for at least three months.

inclusion criteria: - informed consent as documented by signature - admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection - evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) - symptom onset within the previous 10 days, i.e. fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment) or shortness of breath within the previous 5 days - expected to remain an inpatient over the next three calender days from time of enrolment - at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) >50 years, 3) obesity (bmi>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of >35mg/l, 7) oxygen saturation at rest in ambient air of <94%

inclusion criteria: - informed consent as documented by signature - admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection - evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) - symptom onset within the previous 10 days, i.e. fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment) or shortness of breath within the previous 5 days - expected to remain an inpatient over the next three calender days from time of enrolment - at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) >50 years, 3) obesity (bmi>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of >35mg/l, 7) oxygen saturation at rest in ambient air of <94%

inclusion criteria: - informed consent as documented by signature - admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection - evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) - symptom onset within the previous 10 days, i.e. fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment) - expected to remain an inpatient over the next three calender days from time of enrolment - at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) >50 years, 3) obesity (bmi>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of >35mg/l, 7) oxygen saturation at rest in ambient air of <94%

inclusion criteria: - informed consent as documented by signature - admitted to the hospital because of confirmed (by a positive sars-cov-2 pcr result) covid-19 infection - evidence of pulmonary involvement on ct scan or x-ray of the chest (e.g. ground glass opacities) - symptom onset within the previous 10 days, i.e. fever or one respiratory symptom (patients presenting later may have already progressed to an inflammatory state that is potentially not amenable to c1inh treatment) - expected to remain an inpatient over the next three calender days from time of enrolment - at least one additional risk factor for progression to mechanical ventilation: 1) arterial hypertension, 2) >50 years, 3) obesity (bmi>30.0 kg/m2), 4) cardiovascular disease, 5) chronic pulmonary disease, 7) chronic renal disease, 6) c-reactive protein of >35mg/l, 7) oxygen saturation at rest in ambient air of <94%