Patients with severe allergies, serious basic illnesses that affect survival, including blood disorders, cachexia, active bleeding, severe malnutrition, obstructive pulmonary pneumonia, severe pulmonary interstitial fibrosis, alveolar proteinosis, allergic alveolitis and other known viral pneumonia or bacterial pneumonia, continuous use of immunosuppressive agents or organ transplants in the last 6 months, cancer being treated or even treated (a formal opinion from the responsible doctor is required), low adherence and unable to complete the full study, increased risk of the subject or other conditions that interfere with the clinical trial and the judgment of results such as excessive stress, sensitivity or cognitive impairment.

Patients with severe allergies, serious basic illnesses that affect survival, including blood disorders, cachexia, active bleeding, severe malnutrition, obstructive pulmonary pneumonia, severe pulmonary interstitial fibrosis, alveolar proteinosis, allergic alveolitis and other known viral pneumonia or bacterial pneumonia, continuous use of immunosuppressive agents or organ transplants in the last 6 months, cancer being treated or even treated (a formal opinion from the responsible doctor is required), low adherence and unable to complete the full study, increased risk of the subject or other conditions that interfere with the clinical trial and the judgment of results such as excessive stress, sensitivity or cognitive impairment.