1. Subjects aged 18-59 years, 2. The subjects who signed the informed consent form and participated voluntarily, 3. Subjects with good compliance, 4. Subjects with the interval of more than 14 days from the last vaccination, 5. Before entering this study, subjects with history and clinical examination and body temperature <= 37.0 degrees C.

1. Subjects aged 18-59 years, 2. The subjects who signed the informed consent form and participated voluntarily, 3. Subjects with good compliance, 4. Subjects with the interval of more than 14 days from the last vaccination, 5. Before entering this study, subjects with history and clinical examination and body temperature <= 37.0 degrees C.

1. Healthy subjects aged 18-59 years old, 2. Able to understand the content of informed consent and willing to sign the informed consent, 3. Able and willing to complete the whole prescribed study plan, 4. Have not received any pneumococcal vaccine, COVID-19 vaccine or seasonal influenza vaccine before enrollment, 5. The interval between the last vaccination is >= 14 days, 6. Body temperature <= 37.0 degrees C before going into this study.

1. Healthy subjects aged 18-59 years old, 2. Able to understand the content of informed consent and willing to sign the informed consent, 3. Able and willing to complete the whole prescribed study plan, 4. Have not received any pneumococcal vaccine, COVID-19 vaccine or seasonal influenza vaccine before enrollment, 5. The interval between the last vaccination is >= 14 days, 6. Body temperature <= 37.0 degrees C before going into this study.