1. Patients with history of allergy, convulsion, epilepsy, encephalopathy and psychosis or family history, 2. Those who are allergic to any component of the vaccine, and those who have had any history of severe allergy to the vaccine (such as acute allergic reaction, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain), 3. Patients with immunodeficiency, cancer treatment, immunosuppressive therapy (oral steroids) or HIV induced hypoimmunity, or close family members with congenital immune diseases, 4. Subjects injected with non-specific immunoglobulin within one month before enrollment, 5. Severe liver and kidney diseases, respiratory system diseases, cardiovascular diseases, malignant tumors, patients with uncontrollable diabetic complications, acute attack of various acute or chronic diseases, various infectious, suppurative and allergic skin diseases, 6. Subjects injected with non-specific immunoglobulin within one month before enrollment, 7. Subjects with acute febrile diseases and infectious diseases whose body temperature is more than 37.0 degrees C, 8. Pregnant or lactating women.

1. Patients with history of allergy, convulsion, epilepsy, encephalopathy and psychosis or family history, 2. Those who are allergic to any component of the vaccine, and those who have had any history of severe allergy to the vaccine (such as acute allergic reaction, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain), 3. Patients with immunodeficiency, cancer treatment, immunosuppressive therapy (oral steroids) or HIV induced hypoimmunity, or close family members with congenital immune diseases, 4. Subjects injected with non-specific immunoglobulin within one month before enrollment, 5. Severe liver and kidney diseases, respiratory system diseases, cardiovascular diseases, malignant tumors, patients with uncontrollable diabetic complications, acute attack of various acute or chronic diseases, various infectious, suppurative and allergic skin diseases, 6. Subjects injected with non-specific immunoglobulin within one month before enrollment, 7. Subjects with acute febrile diseases and infectious diseases whose body temperature is more than 37.0 degrees C, 8. Pregnant or lactating women.

1. History or family history of seizure, eclampsia, epilepsy, brain or mental disease, 2. Intolerance or allergy to any component of the vaccine, 3. Severe liver and kidney diseases, respiratory diseases, cardiovascular diseases, hemopathy, cancer, immunodeficiency, 4. Subjects were injected with non-specific immunoglobulin within 1 month before admission, 5. Complications of uncontrolled diabetes, acute episodes of various acute or chronic diseases, 6. Specific immunoglobulin was injected within 1 month prior to enrollment, 7. Acute illness with fever (body temperature >= 37.1 degrees C) and infectious diseases, 8. Being pregnant or breastfeeding.

1. History or family history of seizure, eclampsia, epilepsy, brain or mental disease, 2. Intolerance or allergy to any component of the vaccine, 3. Severe liver and kidney diseases, respiratory diseases, cardiovascular diseases, hemopathy, cancer, immunodeficiency, 4. Subjects were injected with non-specific immunoglobulin within 1 month before admission, 5. Complications of uncontrolled diabetes, acute episodes of various acute or chronic diseases, 6. Specific immunoglobulin was injected within 1 month prior to enrollment, 7. Acute illness with fever (body temperature >= 37.1 degrees C) and infectious diseases, 8. Being pregnant or breastfeeding.