inclusion criteria: 1. subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. 2. subject is ≥18 years of age at the time of informed consent and assent (as applicable). 3. subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. 4. subject has a diagnosis of covid-19 infection through an approved testing method. 5. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with partial pressure of arterial oxygen/percentage of inspired oxygen (pao2/fio2) \>100 and \<300. 6. subject's oxygen saturation at rest in ambient air \<93%

inclusion criteria: 1. subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. 2. subject is ≥18 years of age at the time of informed consent and assent (as applicable). 3. subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. 4. subject has a diagnosis of covid-19 infection through an approved testing method. 5. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with partial pressure of arterial oxygen/percentage of inspired oxygen (pao2/fio2) \>100 and \<300. 6. subject's oxygen saturation at rest in ambient air \<93%

inclusion criteria: subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. subject is ≥18 years of age at the time of informed consent and assent (as applicable). subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. subject has a diagnosis of covid-19 infection through an approved testing method. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with partial pressure of arterial oxygen/percentage of inspired oxygen (pao2/fio2) >100 and <300. subject's oxygen saturation at rest in ambient air <93%

inclusion criteria: subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. subject is ≥18 years of age at the time of informed consent and assent (as applicable). subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. subject has a diagnosis of covid-19 infection through an approved testing method. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with partial pressure of arterial oxygen/percentage of inspired oxygen (pao2/fio2) >100 and <300. subject's oxygen saturation at rest in ambient air <93%

inclusion criteria: subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. subject is ≥18 years of age at the time of informed consent and assent (as applicable). subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. subject has a diagnosis of covid-19 infection through an approved testing method. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with pao2/fio2 >100 and <300. subject's oxygen saturation at rest in ambient air <93%

inclusion criteria: subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. subject is ≥18 years of age at the time of informed consent and assent (as applicable). subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. subject has a diagnosis of covid-19 infection through an approved testing method. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with pao2/fio2 >100 and <300. subject's oxygen saturation at rest in ambient air <93%

inclusion criteria: 1. subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. 2. subject is ≥18 years of age at the time of informed consent and assent (as applicable). 3. subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. 4. subject has a diagnosis of covid-19 infection through an approved testing method. 5. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with pao2/fio2 >100 and <300. 6. subject's oxygen saturation at rest in ambient air <93%

inclusion criteria: 1. subject/legally authorized representative (lar) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study. 2. subject is ≥18 years of age at the time of informed consent and assent (as applicable). 3. subject is male or non-pregnant, non-lactating female, who if of childbearing potential agrees to comply with any applicable contraceptive requirements if. discharged from the hospital prior to completing the study. 4. subject has a diagnosis of covid-19 infection through an approved testing method. 5. subject has been hospitalized due to clinical diagnosis of pneumonia with acute lung injury defined as diffuse bilateral radiographic infiltrates with pao2/fio2 >100 and <300. 6. subject's oxygen saturation at rest in ambient air <93%