1. Known or suspected intolerance or hypersensitivity to povidone-iodine or other study materials (or closely related compounds) or any of their stated ingredients 2. Known pregnancy, currently breastfeeding or women of childbearing age without effective contraception 3. Current requirement for invasive or non-invasive ventilation, or planned within next 6 hours 4. Known dermatitis herpetiformis (Duhring's disease) 5. Inability to communicate in English or read English

1. Known or suspected intolerance or hypersensitivity to povidone-iodine or other study materials (or closely related compounds) or any of their stated ingredients 2. Known pregnancy, currently breastfeeding or women of childbearing age without effective contraception 3. Current requirement for invasive or non-invasive ventilation, or planned within next 6 hours 4. Known dermatitis herpetiformis (Duhring's disease) 5. Inability to communicate in English or read English