Created at Source Raw Value Validated value
Nov. 12, 2020, 11:45 p.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "The study consists of a single treatment with no follow-up. Participants will be assigned to one of the four arms using a balanced randomisation scheme: Dentyl Mouthwash (Cetylperidium chloride 0.05% [v/v]); povidone-iodine (PVP-I 0.5% [v/v]); Ultradex (Cetylperidium chloride 0.1% [v/v]) or Normasol (sterile saline 0.9% [v/v]). The three test (active) agents will all be used according to their current marketing approval. Baseline saliva will be collected before the participant rinses their mouth with 10 ml of one of the three active mouthwashes or saline mouthwash; depending on allocation. Infectious virus in salivary samples will be quantitated by performing serial dilutions in DMEM/FBS; and inoculating Vero E6 monolayers for 1 hour; then overlaying with 2% Avicel. After 3 days; Avicel will be removed; and plaques enumerated. Plaques will be stained with anti-spike (S2) antibody to confirm the identity of the isolated virus by immunofluorescence. Viral genomes will also be extracted from saliva and quantitated by RT-qPCR; using established primer sets.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "0.05%", "treatment_id": 268, "treatment_name": "Cetylpyridinium chloride", "treatment_type": "Mouthwash", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "0.1%", "treatment_id": 268, "treatment_name": "Cetylpyridinium chloride", "treatment_type": "Mouthwash", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 1015, "treatment_name": "Povidone-iodine", "treatment_type": "Mouthwash", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]