1. Healthy adults aged 18-59 who can provide the legal identification of the subjects, both male and female, 2. The subjects knew the content of the informed consent and the vaccination situation, voluntarily signed the informed consent, and had the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Those who can communicate well with researchers, and understand and comply with the requirements of this study, 4. The subjects with axillary temperature < 37.3 degree C on the day of inoculation.

1. Healthy adults aged 18-59 who can provide the legal identification of the subjects, both male and female, 2. The subjects knew the content of the informed consent and the vaccination situation, voluntarily signed the informed consent, and had the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Those who can communicate well with researchers, and understand and comply with the requirements of this study, 4. The subjects with axillary temperature < 37.3 degree C on the day of inoculation.

1. Healthy adults aged 18-59 years who can provide legal identity certificate of their own, both males and females are acceptable, 2. Subjects who understand the contents of the informed consent form and the background of the investigation vaccine, agree to sign the informed consent form voluntarily, and are able to use thermometer and scale, and may fill in the diary card and contact card as required, 3. Subjects who are able to have good communicate with investigator(s), understand and comply with the requirements of this study, 4. Axillary temperature<37.3 degree C on the day of vaccination.

1. Healthy adults aged 18-59 years who can provide legal identity certificate of their own, both males and females are acceptable, 2. Subjects who understand the contents of the informed consent form and the background of the investigation vaccine, agree to sign the informed consent form voluntarily, and are able to use thermometer and scale, and may fill in the diary card and contact card as required, 3. Subjects who are able to have good communicate with investigator(s), understand and comply with the requirements of this study, 4. Axillary temperature<37.3 degree C on the day of vaccination.